2012 Fiscal Year Final Research Report
Trial of the pulmonary ischemic re-perfusion injury suppression by the suppression of the mitochondrial injury
| Project/Area Number |
22591565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847)
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Meinoshin 大阪大学, 医学系研究科, 教授 (40252647)
SAWABATA Noriyoshi 大阪大学, 医学系研究科, 准教授 (50403184)
INOUE Masayoshi 大阪大学, 医学系研究科, 講師 (10379232)
KADOTA Yoshihisa 大阪大学, 医学系研究科, 助教 (50464243)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肺移植 / 虚血再灌流障害 / ミトコンドリア障害 |
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| Research Abstract |
The main factor affecting the outcome of the lung transplantation is chronic resection. It is said that one of the causesis the presence of the ischemia re-perfusion injury after transplantation. An intense mitochondrial injury appears at the time of re-perfusion. Mitochondrial injury (PT: permeability transition) is derived through oxidation stress at the time of re-perfusion, and at that time, a large quantity of mitochondrial protein leaks. Mitochondrial protein outflow was suppressed by the hydrogen inhalation, and a pulmonary ischemia re-perfusion was suppressed.
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