2012 Fiscal Year Final Research Report
Analysis of tumor hypoxia in lung cancer using real time mass spectrometry
| Project/Area Number |
22591567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
MIYATA Yoshihiro 広島大学, 原爆放射線医科学研究所, 准教授 (50397965)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Morihito 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 呼吸器外科学 / FDG-PET |
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| Research Abstract |
In lung adenocarcinoma, the SUVmax and the expression of HIF1α and GLUT1 correlated with various clinicopathological factors relating to malignancy and disease free survival. We conclude that in lung adenocarcinoma, but not squamous cell carcinoma, HIF1α-induced GLUT1 expression indicates tumor aggressiveness pathologically, and might explain high FDG uptake on PET and correlate with poor prognosis. We also show that proline and glutamate metabolism may play a role in 5-FU induced cell death using real time mass spectrometry.
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