2012 Fiscal Year Final Research Report
Preventive effect of marrow stromal cells on stroke and neurodegenerative disease
| Project/Area Number |
22591589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
MOGI Masaki 愛媛大学, 大学院・医学系研究科, 准教授 (20363236)
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Masashi 愛媛大学, 大学院・医学系研究科, 教授 (40150338)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アンジオテンシンII / 脳梗塞 / 認知症 / 骨髄細胞 / 糖尿病 / 血液脳関門 |
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| Research Abstract |
We investigated the effect of renin-angiotensin system (RAS) on stroke and dementia. RAS in marrow-derived cells regulated stroke size using chimeric mice which were replaced bone marrows by other kinds of mice. Moreover, regulation of RAS prevented diabetes-induced dementia via inhibition of blood-brain barrier using diabetic mice, KKAy.
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