The influence of genetic polymorphism on preoperative platelet function testing in patients undergoing Carotid Artery Stenting

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591591
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyushu University
• Principal Investigator: MATSUMOTO Shoji 九州大学, 大学病院, 講師 (00570772)
• Co-Investigator(Kenkyū-buntansha): KIRA Jun-ichi 九州大学, 大学院・医学研究院, 教授 (40183305) ; OHOYAGI Yasumasa 九州大学, 大学院・医学研究院, 教授 (30301336) ; FURUTA Kounoske 九州大学, 大学病院, 特任助教 (60546571)
• Project Period (FY): 2010 – 2012
• Keywords: 頚動脈ステント留置術 / 抗血小板薬不応性 / 遺伝子多型 / クロピドグレル / CYP2C19 / Verify now

Research Abstract

The proportion of the CYP2C19 loss-of-function alleles (*2,*3) was relatively high and CYP2C19 gain-of-function allele (*17) was rare in the Japanese patients undergoingcarotid artery stenting. The proportion of non-responder of clopidogrel is higher in patients with CYP2C19 LOF allele. There was no significant association between non-responder of clopidogrel and periprocedural complication.

Research Products

• [Presentation] The antiplatelet effect of clopidogrel therapy inJapanese patients undergoing neurointervention Japan not associated with PON-1 Q192R polymorphism (2012)
  • Author(s): Shoji Matsumotoet.al
  • Organizer: The 10th meeting of Asian-Australasian Federation of Intervenitonal and Therapeutic Neuroradiology (AAFITN 2012)
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2012-06-14
• [Presentation] The antiplatelet effect of clopidogrel is associated with CYP2C19 *2 and *3 polymorphism but not with PON-1 Q192R polymorphism in Japanese patients undergoing neurointervention (2012)
  • Author(s): Shoji Matsumotoet.al
  • Organizer: International Stroke Conference 2012
  • Place of Presentation: New Orleans(USA)
  • Year and Date: 2012-02-01
• [Presentation] (2011)
  • Author(s): 松本省二ほか
  • Organizer: 第27回日本脳神経血管内治療学会総会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-24
• [Presentation] 脳血管内治療周術期の抗血小板薬不応症の解析 (2011)
  • Author(s): 松本省二ほか
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2011-07-31
• [Presentation] 脳血管内治療患者における CYP2C19 遺伝子多型解析とクロピドグレル治療効果の関連 (2011)
  • Author(s): 松本省二ほか
  • Organizer: 第52回日本神経学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-05-19
• [Presentation] 脳血管内治療周術期の抗血小板薬不応症の解析 (2010)
  • Author(s): 松本省二ほか
  • Organizer: 第26回NPO法人日本脳神経血管内治療学会学術総会
  • Place of Presentation: 北九州国際会議場(北九州市)
  • Year and Date: 2010-11-18