Brain changes and computer simulation of chronic repetitive transcranial magnetic stimulation (rTMS)

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591608
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: SAITOH Youichi 大阪大学, 産学連携本部, 特任教授 (20252661)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Manabu 大阪大学, 医学系研究科, 助教 (40448064) ; MARUO Tomoyuki 大阪大学, 医学部附属病院, 特任助教 (90533810) ; SEKINO Masaki 大阪大学, 工学系研究科, 准教授 (20401036) ; HOSOMI Kouichi 大阪大学, 産学連携本部, 特任助教
• Project Period (FY): 2010 – 2012
• Keywords: 機能脳神経外科学

Research Abstract

We made a computer simulation of rTMS in order to anticipate Eddy current in cerebral cortex. From MRI image, brain and other structures were divided, and distribution of Eddy current was calculated as 5mm mesh. It’ s important to analyze local blood flow of cerebral cortex after rTMS. After stimulation with figure-8-coil of 20mm diameter, the cortical local blood flow was measured by Speckle rheometry. 5Hz rTMS made the increase of local blood flow .

Research Products

• [Journal Article] High-frequency repetitive transcranial magnetic stimulation for three consecutive days in Parkinson's disease (2013)
  • Author(s): Maruo T, Hosomi K, Shimokawa T, Kishima H, Oshino S, Morris S, Kageyama Y, Yokoe M, Yoshimine T, Saitoh Y.
  • Journal Title: Brain stim(in press)
  • Peer Reviewed
• [Journal Article] Daily repetitive transcranial magnetic stimulation of primary motor cortex for neuropathic pain: a randomized, multicenter, double-blind, crossover, sham-controlled trial. (2013)
  • Author(s): Hosomi K, Shimokawa T, Ikoma K, Nakamura Y, Sugiyama K, Ugawa Y, Uozumi T, Yamamoto T, Saitoh Y.
  • Journal Title: Pain
  • Peer Reviewed
• [Journal Article] Cortical excitability changes after high-frequency repetitive transcranial magnetic stimulation for central post-stroke pain (2013)
  • Author(s): Hosomi K, Kishima H, Oshino S, Hirata M, Tani N, Maruo T, Yorifuji S, Yoshimine T, Saitoh Y.
  • Journal Title: Pain
  • Peer Reviewed
• [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients. (2012)
  • Author(s): Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Matsushita K, Goto T, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
  • Journal Title: Ann Neurol Volume: 71 Pages: 353-61
  • DOI: DOI:10.1002/ana.22613
  • Peer Reviewed
• [Journal Article] Regulation of motor representation by phase-amplitude coupling in the sensorimotor cortex. (2012)
  • Author(s): Yanagisawa T, Yamashita O, Hirata M, Kishima H, Saitoh Y, Goto T, Yoshimine T, Kamitani Y
  • Journal Title: J Neurosci Volume: 31 Pages: 15467-75
  • DOI: DOI:10.1523/JNEUROSCI.2929
  • Peer Reviewed
• [Journal Article] Validation and the future of stimulation therapy of the primary motor cortex. (2012)
  • Author(s): Saitoh Y.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 52 Pages: 451-6
  • Peer Reviewed
• [Journal Article] Differential efficacy of electrical motor cortex stimulation and lesioning of the dorsal root entry zone for continuous versus paroxysmal pain after brachial plexus avulsion. (2011)
  • Author(s): Aly MM, Saitoh Y, Hosomi K, Oshino S, Kishima H, Morris S, Shibata M,Yoshimine T .
  • Journal Title: Neurosurgery Volume: 114 Pages: 1252-8
  • DOI: DOI:10.3171/2011.1.JNS101421.
  • Peer Reviewed
• [Journal Article] Importance of disctinction between paroxysmal and continuous patterns of pain during evaluation of pain after brachial plexus injury. (2011)
  • Author(s): Aly MM, Saitoh Y, Kishima H, Hosomi K, Yoshimine T .
  • Journal Title: Acta Neurochir Volume: 153 Pages: 437-8
  • DOI: DOI:10.1007/s00701-010-0874-4.
  • Peer Reviewed
• [Journal Article] Reply to Letter to the Editor: Spinal cord stimulation for thalamic or central pain. (2011)
  • Author(s): Aly MM, Saitoh Y, Oshino S, Hosomi K,Kishima H, Yoshimine T .
  • Journal Title: Neurosurgery Volume: 68 Pages: 1507-8
  • DOI: DOI:10.1227/NEU.0b013e31820c04a9.
  • Peer Reviewed
• [Journal Article] Quantitative analysis of phosphenes induced by navigation-guided repetitive transcranial magnetic stimulation. (2011)
  • Author(s): Tani N, Hirata M, Motoki Y, Saitoh Y, Yanagisawa T, Goto T, Hosomi K, Kozu A, Kishima H, Yorifuji S, Yoshimine T.
  • Journal Title: Brain Stimul Volume: 4 Pages: 28-37
  • DOI: DOI:10.1016/j.brs.2010.03.006.
  • Peer Reviewed
• [Journal Article] Deep brain stimulation of the subthalamic nucleus improved temperature sensation in patients with Parkinson's disease (2011)
  • Author(s): Maruo T, Saitoh Y, Hosomi K, Kishima H, Shimokawa T, Hirata M, Goto T, Morris S, Harada Y, Yanagisawa T, Aly MM, Yoshimine T
  • Journal Title: Pain Volume: 152 Pages: 860-5
  • DOI: DOI:10.1016/j.pain.2010.12.038.
  • Peer Reviewed
• [Journal Article] Novel methods to evaluate symptoms in Parkinson's disease - Rigidity and finger tapping. (2011)
  • Author(s): Yokoe M, Endo T, Fujimura H, Sakoda S.
  • Journal Title: Diagnostics and Rehabilitation of Parkinson's Disease. Volume: 9 Pages: 191-206
  • DOI: DOI:10.5772/17967
  • Peer Reviewed