2012 Fiscal Year Final Research Report
Development of a new animal model of chronic low back pain utilizing analysis of pain behaviors and elucidation of pain mechanisms
| Project/Area Number |
22591640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ENYO Yoshio 和歌山県立医科大学, 医学部, 助教
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| Project Period (FY) |
2010 – 2012
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| Keywords | A 脊椎脊髄病学 |
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| Research Abstract |
We demonstrated that bilateral resection of the facet joints results in intervertebral disc degeneration and segmental instability without spondylolisthesis in the rat. In this animal model, behavioral analysis utilizing CatWalk revealed pain-related behaviors 7 weeks after operation and increase in neurotransmitter related to pain and proinflammatory cytokines were seen in the affected dorsal root ganglia. In addition, we found that the pain-related behaviors were related to nociceptive and neurogenic pain. Further studies are needed to elucidate if the pain-related behaviors result from degenerative process of the intervertebral disc itself influence or irritation of the cauda equina and/or the nerve root secondary to segmental instability in this animal model.
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[Journal Article] Disk dynamic compression in rats produces long-lasting increases in inflammatory mediators in disks and induceslong-lasting nerve injury and regeneration of the afferent fibers innervating discs: A pathomechanism for chronic discogenic low back pain.2012
Author(s)
Miyagi M, Ishikawa T, Kamoda H, Suzuki M, Murakami K, Shibayama M, Orita S, Eguchi Y, Arai G, Sakuma Y, Kubota G, Oikawa Y, Ozawa T, Aoki Y, Toyone T, Takahashi K, Inoue G, Kawakami M, Ohtori S.
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Journal Title
Spine
Volume: 37 (21)
Pages: 1810-1818
Peer Reviewed
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