2012 Fiscal Year Final Research Report
Sphingosine 1-phosphate/S1P receptor axis as a molecular target for therapeutic intervention after spinal cord injury
| Project/Area Number |
22591641
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHMORI Tsukasa 自治医科大学, 医学部, 講師 (70382843)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脊髄損傷 / 生理活性脂質 |
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| Research Abstract |
FTY720 is phosphorylated in vivo to produce the active metabolite FTY720-P, which is a nonselective S1P receptor agonist for four of the five known S1P receptors. We examined the therapeutic effects of FTY720 on locomotor recovery after SCI in mice. Oral
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