2012 Fiscal Year Final Research Report
The synergy between bFGF and bisphosphonate contributes to fracture healing
| Project/Area Number |
22591661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | リコンビナントヒト線維芽細胞増殖因子-2 / rhFGF-2 / 骨リモデリング / ビスホスフォネート / 骨強度 / 骨質 |
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| Research Abstract |
Bone repair involves a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone matrix at the fracture site. The resultssuggested that the recombinant human fibroblast growth factor (rhFGF-2) increased the bone formation and mechanical strength. The synergic effect of rhFGF-2 and ZA given systemically as a single dose at the optimal time was efficacious for fracture repair and significantly enhanced bone fusion. Our results suggest that this combination facilitates bone healing and has potential clinical application.
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