2012 Fiscal Year Final Research Report
Establishment of immunotherapy with chemotherapy in osteosarcomas
| Project/Area Number |
22591671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUNAGA Satoru 兵庫医科大学, 医学部, 助教 (40441290)
TERADA Nobuyuki 兵庫医科大学, 医学部, 教授 (50150339)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨肉腫 / 肺転移 / 化学療法 / 免疫療法 / 悪性骨腫瘍 |
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| Research Abstract |
We investigated the effects of valproic acid (VPA) (a histone deacetylase inhibitor) in combination with hydralazine (Hy) (a DNA methylation inhibitor) to enhance the therapeutic effects of immunotherapy of interleukin-18 in osteosarcomas.
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Research Products
(14 results)
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[Journal Article] Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.2012
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N.
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Journal Title
Oncol Rep.
Volume: 28(5)
Pages: 1585-1590
DOI
Peer Reviewed
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[Journal Article] Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma2012
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, YamadaN, Hata M, Fukunaga S, Futani H, Okamura H, Terada N.
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Journal Title
cells to Fas- and NK cell-mediated cell death.Int J Oncol.
Volume: 41(1)
Pages: 83-91
DOI
Peer Reviewed
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[Journal Article] Terada N. Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.2010
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Nishioka T, Fukunaga S, Futani H, Okamura H
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Journal Title
Oncol Rep
Volume: 24(6)
Pages: 1621-1627
URL
Peer Reviewed
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