2012 Fiscal Year Final Research Report
Evaluation of the analgesic effect of new compounds DHLHZN onadjuvant-induced pain in the rat
| Project/Area Number |
22591739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKATANI Juniji 大分大学, 医学部, 助教 (50537107)
OKUDA Kentaro 大分大学, 医学部, 講師 (60284808)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 抗酸化物質 / 亜急性疼痛 / 鎮痛効果 / αリポ酸 / フリーラジカル |
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| Research Abstract |
It was found that fewer side effects where use adjuvant-induced pain model in the rat, was administered subcutaneously daily to DHLHZN. Because that withdrawal latency by plantar test increased, infiltration of inflammatory cells was inhibited, the tissue MPO(Myeloperoxidase) concentration decreased, likely to have analgesic effect of DHLHZN by anti-inflammatory action was suggested. Next, we examined DHLHZN whether having an analgesic effect in dose-dependency, whether having an analgesic effect in after the administration subcutaneously, but was not proven.
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