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2012 Fiscal Year Final Research Report

Treatment and measurement of neuropathic pain using acromelic acid analogues

Research Project

  • PDF
Project/Area Number 22591753
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka Medical College

Principal Investigator

MINAMI Toshiaki  大阪医科大学, 医学部, 教授 (00257841)

Co-Investigator(Kenkyū-buntansha) SOEN Masako  大阪医科大学, 医学部, 助教 (90445982)
FUJIWARA Shunsuke  大阪医科大学, 医学部, 助教 (60535813)
MORIMOTO Kenji  大阪医科大学, 医学部, 助教 (20388250)
MIYAZAKI Shinichiro  大阪医科大学, 医学部, 助教 (30411359)
KUSAKA Yusuke  大阪医科大学, 医学部, 助教 (60636075)
Co-Investigator(Renkei-kenkyūsha) FURUTA Kyoji  岐阜大学, 大学院・医学系研究科再生医科学専攻・医学(系)研究科(研究院), 准教授 (40173538)
Project Period (FY) 2010 – 2012
Keywordsアクロメリン酸 / アロディニア / 神経障害性疼痛
Research Abstract

We previously showed that intrathecal (i.t.) administration ofacromelic acid A (Acro-A), a major causing substance of the mushroom (Clitocybeacromelalga) poison, provoked allodynia in conscious mice. To clarify a mechanism ofAcro-A, we synthesized [11C]-labeled Acro-A analogue (PSPA-4) that can competitivelyblock the Acro-A-induced allodynia. In vitro autoradiography, [C]PSPA-4 wasspecifically bound to the rat brain and spinal cord, and the binding was significantlydisplaced by kainic acid, but not by antagonists of kainate receptor. PSPA-4 attenuatedthe Acro-A-induced allodynia at low doses and induced allodynia at high doses via a bindingsite different from known kainate antagonists. The development of a radio-labeled Acro-Aanalogue will enable us to promote the understanding of the action mechanism not onlyof Acro-A, but also of pain transmission in the periphery and central nervous system.

  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (2 results)

  • [Journal Article] The action site of the synthenic kainoid(2S, 3R, 4R)-3-carboxymethyl-4(4-methylphenylthio)pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, on allodynia (tactile pain).2013

    • Author(s)
      Miyazaki, S., Minami, T., Mizuma, H.,Kanazawa, M., Doi, H., Matsumura, S., Lu,J., Onoe, H., Furuta, K., Suzuki, M., Ito,S.
    • Journal Title

      Eur. J.Pharmacol.

      Volume: 120-127

    • DOI

      doi: 10.1016/j.ejphar.2012.10.023.

    • Peer Reviewed
  • [Journal Article] Proteomic analysis of the cerebrospinalfluid before and after intrathecalinjection of steroid into patients withpostherpetic pain.2013

    • Author(s)
      Lu, J., Katano, T., Nishimura, W.,Fujiwara, S., Miyazaki, S., Okasaki, I.,Aritake K, Urade, Y., Minami, T., ItoS.
    • Journal Title

      Eur. JPharmacol.

      Volume: 120-127

    • DOI

      doi: 10.1016/j.ejphar.2012.10.023.

    • Peer Reviewed
  • [Journal Article] Identification of NIPSNAP1 as anocistatin-interacting proteininvolving pain transmission.2012

    • Author(s)
      Okuda-Ashitaka, E., Minami, T.,Tsubouchi, S., Kiyonari, H., Iwamatsu,A., Noda, T., Handa, H., Ito, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 10403-10413

    • DOI

      doi: 10.1074/jbc.M111.271866.

    • Peer Reviewed
  • [Journal Article] Synthesis of an acromelic acid Aanalog-based 11C-labeled PET tracer forexploration of the site of action ofacromelic acid A in allodynia induction.2011

    • Author(s)
      Kanazawa, M., Furuta, K., Doi, H., Mori,T., Minami, T., Ito, S., Suzuki, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 21 Pages: 2017-2020

    • DOI

      doi: 10.1074/jbc.M111.271866.

    • Peer Reviewed
  • [Presentation] The action site of the synthenic kainoid(2S, 3R, 4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylic acid (PSPA-4), an analogue ofJapanese mushroom poison acromelic acid,for allodynia (tactile pain).2012

    • Author(s)
      Miyazaki, S., Minami, T., Mizuma, H.,Kanazawa, M., Doi, H., Matsumura, S., Lu,J., Onoe, H., Furuta, K., Suzuki, M., Ito,S.
    • Organizer
      The 14th World Congress on Pain. 29
    • Place of Presentation
      Milan
    • Year and Date
      20120800
  • [Presentation] Characterization of postherpeticneuralgia in mice with knock-in mutationof NMDA receptor.2012

    • Author(s)
      Ito, S., Sasaki, A., Unezaki, S., Andoh,T., Matsumura, S., Katano, T., Nishio, N.,Nakatsuka, T., Kuraishi, Y., Minami, T.
    • Organizer
      The 14th World Congress on Pain. 31
    • Place of Presentation
      Milan
    • Year and Date
      20120800
  • [Presentation] 神経ペプチドノシスタチン結合タンパク質の炎症性疼痛への関与2012

    • Author(s)
      岡本和哉, 南 敏明, 伊藤誠二, 芦高恵美子
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
  • [Presentation] 術後急性痛:遷延性術後痛の機序と予防外科手術に関連した神経障害性疼痛2012

    • Author(s)
      西村 渉, 藤原俊介, 南 敏明
    • Organizer
      日本ペインクリニック学会第46回大会
    • Place of Presentation
      松江
    • Year and Date
      2012-07-07
  • [Presentation] アクロメリン酸誘導体を用いたオートラジオグラフィー・カルシウムイメージングによる脳・脊髄の痛みの可視化2012

    • Author(s)
      宮崎信一郎 南 敏明, 水間 広, 尾上浩隆, 古田享史, 伊藤誠二
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-06-07
  • [Book] 神経障害性疼痛の治療1. 薬物療法K. 将来に期待できる疼痛治療薬-For Professional Anesthesiologists-神経障害性疼痛編: 真下 節2011

    • Author(s)
      南 敏明V
    • Total Pages
      298-304
    • Publisher
      克誠堂出版, 東京
  • [Book] 第3 部治療臨床を意識したこれからの疼痛治療薬開発動第1 章有望な鎮痛カスケードの開発動向第14 節プロスタグランジン拮抗薬慢性疼痛における薬剤選定と治療薬開発企画編集: 佐藤章弘,発行人: 高薄一弘2010

    • Author(s)
      南 敏明
    • Total Pages
      370-375
    • Publisher
      技術情報協会, 東京

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Published: 2014-08-29  

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