Development of optimized hemodynamic therapy guided by mean circulatory filling pressure or stressed blood volume.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: SHISHIDO Toshiaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (60300977)
• Co-Investigator(Kenkyū-buntansha): MURATA Yoshihiro 独立行政法人国立循環器病研究センター, 病院, 医師 (10572092)
• Co-Investigator(Renkei-kenkyūsha): SHIMIZU Shuji 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (80443498) ; KAWADA Toru 独立行政法人国立循環器病研究センター, 研究所, 室長 (30243752) ; UEDA Shinya 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (40616926)
• Project Period (FY): 2010 – 2012
• Keywords: 有効循環血液量 / 循環系平均充満圧 / 血行動態管理 / 血行動態モデル

Research Abstract

Although intravenous therapy is important in performing intensive care or perioperative management, its effectiveness depends greatly on the skill or experience of medical specialists. The present study examined the possibility of new hemodynamic optimization therapy guided by mean circulatory filling pressure or stressed blood volume in the comprehensive Guyton's cardiovascular model. It seemed that the stressed blood volume is suitable for this optimization therapy because the stressed blood volume has a wider dynamic range for hemodynamic change than the mean circulatory filling pressure. The patient feasibility study with acute heart failure suggested that either the mean circulatory filling pressure or the stressed blood volume may quantify the optimal timing to administer positive inotropes.

Research Products

• [Journal Article] Effects of exercise training on gut hormone levels after a single bout of exercise in middle-aged Japanese women. (2013)
  • Author(s): Ueda SY, Miyamoto T, Nakahara H, Shishido T, Usui T, Katsura Y, Yoshikawa T, Fujimoto S.
  • Journal Title: SpringerPlus Volume: 2 Pages: 83
  • DOI: DOI:10.1186/2193-1801-2-83
  • Peer Reviewed
• [Journal Article] A heart transplant candidate with severe pulmonary hypertension and extremely high pulmonary vascular resistance. (2013)
  • Author(s): Sato T, Seruchi O, Morikawa N, Hieda M, Watanabe T, Sunami H, Murata Y, Yanase M, Hata H, Fujita T, Nakatani T.
  • Journal Title: J Artif Organs.
  • DOI: DOI:10.1007/s10047-013-0695-3
  • Peer Reviewed
• [Journal Article] Serial changes in renal function as a prognostic indicator in advanced heart failure patients with left ventricular assist system. (2012)
  • Author(s): Iwashima Y, Yanase M, Horio T, Seguchi O, Murata Y, Fujita T, Toda K, Kawano Y, Nakatani T.
  • Journal Title: Ann Thorac Surg. Volume: 93(3) Pages: 916-23
  • DOI: DOI:10.1016/j.athoracsur.2011.11.058
  • Peer Reviewed
• [Journal Article] Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis. (2010)
  • Author(s): Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M.
  • Journal Title: J Physiol Sci Volume: 60(3) Pages: 205-12
  • DOI: DOI:10.1007/s12576-010-0086-y
  • Peer Reviewed
• [Presentation] Reduction of myocardial oxygen demand by controlling heart rate and hemodynamics simultaneously by novel circulatory model. (2011)
  • Author(s): Sugimachi M, Uemura K, Kawada T, Shishido T, Sunagawa K.
  • Organizer: 33^<rd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2011-09-01
• [Presentation] Autopilot system enables simultaneous hemodynamic normalization and cardiac protection. (2010)
  • Author(s): Sugimachi M, Uemura K, Shishido T, Shimizu S, Sunagawa K.
  • Organizer: Cardiovascular System Dynamic Society.
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-26
• [Presentation] Preoperative right ventricular pump function predicts the feasibility of weaning from inotropic support after implantation of left ventricular assist system. (2010)
  • Author(s): Murata Y, Shishido T, Seguchi O, Yanase M, Fujita T, Toda K, Uemura K, Sugimachi M, Nakatani T.
  • Organizer: Cardiovascular System Dynamic Society.
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-26
• [Presentation] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change. (2010)
  • Author(s): Sugimachi M, Sunagawa K, Uenmura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentine.
  • Year and Date: 2010-09-03
• [Presentation] Physiological significance of pressure-volume relationship : A load-independent index and a determinant of pump function. (2010)
  • Author(s): Sugimachi M, Sunagawa K, Uemura K, Shishido T.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentine
  • Year and Date: 2010-09-03
• [Presentation] 左心補助人工心臓埋込み術前の心ポンプ機能評価から術後の強心剤離脱困難症例を予測できるか? (2010)
  • Author(s): 村田欣洋、宍戸稔聡、中島育太郎、瀬口理、築瀬正伸、藤田知之、戸田宏一、上村和紀、杉町勝、中谷武嗣
  • Organizer: 日本循環制御医学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-05-28