2012 Fiscal Year Final Research Report
Laminin-like molecule is a potent therapeutic and diagnostic target for bladder cancer.
| Project/Area Number |
22591762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHUIN Taro 高知大学, 医学部, 教授 (70128601)
SHUO Takuya 東京大学, 医科学研究所, 特任研究員 (90399006)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腫瘍マーカー / 膀胱がん / ラミニン / 診断 |
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| Research Abstract |
In this study we demonstrated for the first time that monomeric laminin gamma2 chain was detected in urines obtained from the patients with early stage of bladder carcinomas by a sandwich ELISA assay using a specific antibody to human monomeric laminin gamma2 chain(To be submitted). Furthermore urinary monomeric laminin gamma2 was expressed not only in invasive but also in surface carcinomas. The diagnostic value of monomeric laminin gamma2 was higher than that of other marker proteins (MTA, NMP-22) of bladder carcinoma urine. These results strongly suggest that urinary monomeric laminin gamma2 has the possibility to be a potent novel tumor marker for bladder carcinoma.
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Research Products
(25 results)
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[Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.2012
Author(s)
Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
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Journal Title
Blood.
Volume: 119(23)
Pages: 5405-16
DOI
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[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.2011
Author(s)
Nagano M, Hoshino D, Koshiba S, Shuo T, Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T, Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M.
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Journal Title
J Biol Chem.
Volume: 286(36)
Pages: 31598-609
DOI
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[Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice.2011
Author(s)
Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M,Nakauchi H, Watanabe M.
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Journal Title
Biochem Biophys Res Commun.
Volume: 406(1)
Pages: 134-40
DOI
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