2012 Fiscal Year Final Research Report
Establishment of a new diagnostic tool for interstitial cystitis using NFkB reporter system
| Project/Area Number |
22591785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TANAKA Hirishi 北海道大学, 大学院・医学研究科, 非常勤講師 (60344470)
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| Co-Investigator(Kenkyū-buntansha) |
NONOMURA Katsuya 北海道大学, 大学院・医学研究科, 教授 (60113750)
MITSUI Takahiko 北海道大学, 病院・泌尿器科, 助教 (90421966)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 間質性膀胱炎 / NFkB / 診断 / サイトカイン |
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| Research Abstract |
In the first study, IL-8 in urine was higher in IC than healthy normal women. Bladder capacity of IC was smaller in IC patients with higher concentration of IL-6, IL-8, TNF- αin urine. In the second study, using chimera rats with GFP-positive bone marrow cells, bone marrow derived stem (BMS) cells did not directly contribute to the regeneration of the bladder with cystitis, although many BMS migrated to the bladder. Data was not obtained from the third study using urothelium with induction of NAT system.
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