2012 Fiscal Year Final Research Report
Strategy targeting neuropeptide receptors in the central and peripheral nervous systems in treatment of underactive bladder
| Project/Area Number |
22591787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGOMI Hiroshi 山梨大学, 医学部附属病院, 助教 (80418714)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 排尿障害 / 膀胱 / 尿道 / 糖尿病 / 脳下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP) / マウス |
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| Research Abstract |
Lower urinary tract function of genetically mutated mice with diabetes mellitus (DM) was evaluated and compared to that of the wild-type mice. The results suggest that in DM mice, mechanism controlling voiding in the forebrain is devoid of appropriate inhibitory function, and thus the animals present reflex micturition. DM mice at age of 30 week-old still retain voiding efficiency more than 80%, albeit moderately present underactive bladder. Intrathecal administration of PACAP-38 increased maximal voiding pressure and partially suppressed external urethral sphincter activity, suggesting the possibility that stimulation of spinal PACAP receptors enhancesbladder contractility and ameliorates efficiency for voiding.
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[Presentation] Vesicular nucleotide transporter (VNUT) is a key molecule for mechanosensing in the human urinary bladder: negative correlation between VNUT expression in human bladder mucosa and first desire to void. (Abstract No. 12)2012
Author(s)
Nakagomi H, Mochizuki T, Miyamoto T, Kira S, Yoshiyama M, Kawahara K, Moriyama Y, Koizumi S, Takeda M.
Organizer
International Continence Society 42nd Annual meeting, China National Convention Centre
Place of Presentation
Beijing, China
Year and Date
20121015-18
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[Presentation] (vesicular nucleotide transporter) plays a crucial role in stretch-evoked ATP release from urothelium.2012
Author(s)
Nakagomi H, Mochizuki T, Miyamoto T, Yoshiyama M, Araki I, Moriyama Y, Koizumi S, Takeda M.
Organizer
American Urological Association Annual Meeting, Georgia World Congress Center
Place of Presentation
Atlanta, Georgia, U.S.A.
Year and Date
20120519-23
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[Presentation] Gene expression patterns of acid-sensing ion channels (ASICs) families in mammalian bladder.2010
Author(s)
Kobayashi H, Yoshiyama M, Inuzuka H, Kira S, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Zakoji H, Tsuchida T, Araki I, Takeda M.
Organizer
International Continence Society 40th/International Uro-Gynecology Association Joint Meeting
Place of Presentation
Toronto, Canada
Year and Date
20100823-0827
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[Presentation] Hypertension and type 2 diabetes mellitus are highly associated with nocturia than metabolic syndrome in Japanese population.2010
Author(s)
Imamura N, Nakagomi H, Yoda Y, Zakoji H, Kobayashi H, Tsuchida T, Fukazawa M, Yoshiyama M, Araki I, Takeda M.
Organizer
International Continence Society 40th /International Uro-Gynecology Association Joint Meeting
Place of Presentation
Toronto, Canada
Year and Date
20100823-0827
