2012 Fiscal Year Final Research Report
The morphological and physiological investigation into the interstitial cells of human and guinea-pig urinary bladder.
| Project/Area Number |
22591793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
SEKI Narihito 九州大学, 医学研究院, 特別研究員 (90294941)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Shinsuke 名古屋大学, 医学部, 准教授 (30192230)
KAJIOKAI Shunichi 九州大学, 医学研究院, 特任准教授 (90274472)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 間質細胞 / 排尿筋 / 膀胱出口閉塞 / カルシウム電流 |
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| Research Abstract |
It is well known that c-kit positive interstitial cells act as pacemaker cells of peristaltic movement. However, the studies of interstitial cells of urinary bladder have not been sufficiently accumulated. Our present study revealed that c-kit positive interstitial cells were solely distributed between muscle bundles in human urinary bladder different from those in gastrointestinal tract. In guinea-pig urinary bladder, bladder outlet obstruction potentiated the amplitude of the spontaneous electrical activities and the oscillatory activities induced by the stimulation of muscarinic and purinergic receptors using micro multiple electrode arrays.Tyrosine kinase inhibitor (sorafenib), gap junction inhibitor (mefloquine) and Rho kinase inhibitor (fasudil) predominantly inhibited the oscillatory contraction induced by muscarinic contraction in human detrusor. These results suggest the novel treatment strategy for lower urinary tract syndrome such as overactive bladder.
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Research Products
(13 results)
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[Journal Article] Japanese Society Of Endourology Laparoscopic Partial Nephrectomy Study Group: Surgical and oncologic outcomes of laparoscopic partial nephrectomy: a Japanese multi-institutional study of 1375 patients2012
Author(s)
Saito H, Matsuda T, Tanabe K, Kawauchi A, Terachi T, Nakagawa K, Iwamura M, Shigeta M,Tatsugami K, Ito A, Machida J, Kawakita M, Kinoshita H, Shinohara N, Ioritani N, Seki T, Arai Y
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Journal Title
J Endourol
Volume: 26 (6)
Pages: 652-659
Peer Reviewed
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[Journal Article] Endogenous cardiac troponin T modulates Ca^<2+> -mediated smooth muscle contraction2012
Author(s)
Kajioka S, Takahashi-Yanaga F, Shahab N,Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
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Journal Title
Sci Rep
Volume: 2
Pages: 979
Peer Reviewed
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[Journal Article] Fifth joint meeting of the American Urological Association and the Japanese Urological Association International Affiliate Society Meeting at the 105th Annual Meeting of the American Urological Association2010
Author(s)
Myers RP, Seki N, Gotoh M, Chai TC, Kaplan SA, Inoue K, Trachtenberg J, Kikuchi E, Nishiyama H, Chang SS, Lee C, Muto S, Ito K, Andriole GL, Eto M, Sumitomo M, Kamba T, Wood CG, Margulis V, Naito S, Egawa S
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Journal Title
Int J Urol
Volume: 17(8)
Pages: 745-753
Peer Reviewed
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