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2012 Fiscal Year Final Research Report

The morphological and physiological investigation into the interstitial cells of human and guinea-pig urinary bladder.

Research Project

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Project/Area Number 22591793
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKyushu University

Principal Investigator

SEKI Narihito  九州大学, 医学研究院, 特別研究員 (90294941)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Shinsuke  名古屋大学, 医学部, 准教授 (30192230)
KAJIOKAI Shunichi  九州大学, 医学研究院, 特任准教授 (90274472)
Project Period (FY) 2010 – 2012
Keywords間質細胞 / 排尿筋 / 膀胱出口閉塞 / カルシウム電流
Research Abstract

It is well known that c-kit positive interstitial cells act as pacemaker cells of peristaltic movement. However, the studies of interstitial cells of urinary bladder have not been sufficiently accumulated. Our present study revealed that c-kit positive interstitial cells were solely distributed between muscle bundles in human urinary bladder different from those in gastrointestinal tract. In guinea-pig urinary bladder, bladder outlet obstruction potentiated the amplitude of the spontaneous electrical activities and the oscillatory activities induced by the stimulation of muscarinic and purinergic receptors using micro multiple electrode arrays.Tyrosine kinase inhibitor (sorafenib), gap junction inhibitor (mefloquine) and Rho kinase inhibitor (fasudil) predominantly inhibited the oscillatory contraction induced by muscarinic contraction in human detrusor. These results suggest the novel treatment strategy for lower urinary tract syndrome such as overactive bladder.

  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] TURP術後の最適なカテーテル抜去日2012

    • Author(s)
      野尻佳克、荒井陽一、関成人、内藤誠二、町田二郎、長谷川友紀、服部良平、松田公志、矢内原仁、岡村菊夫
    • Journal Title

      Jpn J Endourol

      Volume: 25 (1) Pages: 118-122

  • [Journal Article] Japanese Society Of Endourology Laparoscopic Partial Nephrectomy Study Group: Surgical and oncologic outcomes of laparoscopic partial nephrectomy: a Japanese multi-institutional study of 1375 patients2012

    • Author(s)
      Saito H, Matsuda T, Tanabe K, Kawauchi A, Terachi T, Nakagawa K, Iwamura M, Shigeta M,Tatsugami K, Ito A, Machida J, Kawakita M, Kinoshita H, Shinohara N, Ioritani N, Seki T, Arai Y
    • Journal Title

      J Endourol

      Volume: 26 (6) Pages: 652-659

    • Peer Reviewed
  • [Journal Article] Endogenous cardiac troponin T modulates Ca^<2+> -mediated smooth muscle contraction2012

    • Author(s)
      Kajioka S, Takahashi-Yanaga F, Shahab N,Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
    • Journal Title

      Sci Rep

      Volume: 2 Pages: 979

    • Peer Reviewed
  • [Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kinse C pathway in carbachol-induced calcium sensitization in α-toxin permeabilized Guinea pig detrusor smooth muscle2012

    • Author(s)
      Shahab N, Kajioka S, Takahashi-Yanaga F,Onimaru M, Matsuda M, Seki N, Naito S
    • Journal Title

      Neurourol & Urodynam

      Volume: 31(4) Pages: 593-9

    • Peer Reviewed
  • [Journal Article] Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle2012

    • Author(s)
      Shahab N, Kajioka S, Seki N, Naito S
    • Journal Title

      Urology

      Volume: 79(5) Pages: 1184.e7-13

    • Peer Reviewed
  • [Journal Article] Disphosphate regulation of adenosine triphosphate sensitive potassium channel in human bladder smooth muscle cells2011

    • Author(s)
      Kajioka S, Shahab N, Asano H, Morita H,Sugihara M, Takahashi-Yanaga F, Yoshihara T, Nakayama S, Seki N, Naito S
    • Journal Title

      J Urol

      Volume: 186 Pages: 736-744

    • Peer Reviewed
  • [Journal Article] Etiology of overactive bladder and its therapeutic perspective--focusing on a myogenic basis for the overactive bladder2010

    • Author(s)
      Kajioka S, Seki N, Shahab N, Yunoki T, Naito S
    • Journal Title

      Fukuoka Acta Medica

      Volume: 101(5) Pages: 94-100

  • [Journal Article] Fifth joint meeting of the American Urological Association and the Japanese Urological Association International Affiliate Society Meeting at the 105th Annual Meeting of the American Urological Association2010

    • Author(s)
      Myers RP, Seki N, Gotoh M, Chai TC, Kaplan SA, Inoue K, Trachtenberg J, Kikuchi E, Nishiyama H, Chang SS, Lee C, Muto S, Ito K, Andriole GL, Eto M, Sumitomo M, Kamba T, Wood CG, Margulis V, Naito S, Egawa S
    • Journal Title

      Int J Urol

      Volume: 17(8) Pages: 745-753

    • Peer Reviewed
  • [Presentation] 長谷川友紀 クリニカルパスを用いた経尿道的前立腺切除術周術期管理の改善:多施設共同研究2012

    • Author(s)
      岡村菊夫、野尻佳克、津島知靖、川喜田睦司、関成人、松田公志、荒井陽一、服部良平、内藤誠二
    • Organizer
      第26回日本泌尿器内視鏡学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-22
  • [Presentation] AMS GreenLight HPS」を用いた前立腺蒸散術(PVP)の有用性に関する前向き研究2012

    • Author(s)
      桑原勝孝、野村博之、山口秋人、黒松 功、伊原博之、関成人、奥野 博、後藤百万、平尾佳彦、内藤誠二
    • Organizer
      第26回日本泌尿器内視鏡学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-22
  • [Presentation] 「AMS GreenLightHPS」を用いた前立腺肥大症に対する蒸散術(PVP)の有用性に関する前向き研究2012

    • Author(s)
      黒松 功、桑原勝孝、伊原博行、鈴木和雄、野村博之、山口秋人、奥野博、関成人、内藤誠二、平尾佳彦、後藤百万、杉村芳樹
    • Organizer
      第19回日本排尿機能学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-08-29
  • [Presentation] 高齢者における経尿道的前立腺蒸散術(TURisV)の安全性、有用性についての検討2012

    • Author(s)
      高橋良輔、柚木貴和、林摩耶、ノーバルシャハブ、梶岡俊一、関成人、内藤誠二
    • Organizer
      第25回日本老年泌尿器科学会
    • Place of Presentation
      徳島
    • Year and Date
      2012-06-01
  • [Presentation] 当院における120ワット高出力光選択的前立腺蒸散術(photoselective vaporization of the prostate: PVP)の効果と安全性に関する前向き研究2012

    • Author(s)
      野村博之、関成人、山口秋人、内藤誠二
    • Organizer
      第1回PVP研究会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-24

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Published: 2014-08-29  

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