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2012 Fiscal Year Final Research Report

endometrial cancer therapy using epigenetically regulated small RNA

Research Project

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Project/Area Number 22591866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

BANNO Kouji  慶應義塾大学, 医学部, 講師 (70265875)

Co-Investigator(Kenkyū-buntansha) YANOKURA Megumi  慶應義塾大学, 医学部, 特任助教 (20433732)
Project Period (FY) 2010 – 2012
Keywords婦人科腫瘍学 / 子宮体癌 / CHFR / miR-34b / タキサン製剤
Research Abstract

It is revealed that CHFR gene is epigenetically regulated in endometrial cancer. CHFR gene methylation is correlated with response to Taxane. Micro RNA is also regulated by DNA methylation in endometrial cancer. miR-34b is important for the oncogenesis of

  • Research Products

    (9 results)

All 2013 2012 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] MicroRNAs in endometrial cancer2013

    • Author(s)
      Banno K, Yanokura M, Kisu I, Yamagami W,Susumu N, Aoki D.
    • Journal Title

      Int J Clin Oncol

      Volume: 18(2) Pages: 186-92

    • DOI

      doi:10.1007/s10147-013-0526-9

    • Peer Reviewed
  • [Journal Article] Endometrial Cancer and Hypermethylation Regulation of DNA and MicroRNA by Epigenetics2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochem Res Int

      Volume: 2012 Pages: 738274

    • DOI

      doi:10.1155/2012/738274

    • Peer Reviewed
  • [Journal Article] Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D.
    • Journal Title

      Epigenomics

      Volume: 4(2) Pages: 147-62

    • DOI

      doi:10.2217/epi.12.13.Review

    • Peer Reviewed
  • [Journal Article] MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)2010

    • Author(s)
      Yanokura M, Banno K, Kobayashi Y, Kisu I, Ueki A, Ono A, Masuda K, Nomura H, Hirasawa A, Susumu N, Aoki D
    • Journal Title

      Oncol Lett

      Volume: 1(6) Pages: 935-940

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22870090

    • Peer Reviewed
  • [Presentation] Aberrant epigenetic DNA hypermethylation in liquid-based endometrial cytology samples: evaluation and potential use in diagnosis.2012

    • Author(s)
      阪埜 浩司
    • Organizer
      37th Europian congress of Cytology
    • Place of Presentation
      ドブロブニク(クロアチア)
    • Year and Date
      2012-10-01
  • [Presentation] 子宮体癌に対する miR-34b とパクリタキセル併用による抗腫瘍効果の検討2012

    • Author(s)
      矢野倉 恵
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
  • [Presentation] 子宮体癌においてエピジェネティックに制御される miR-34b の同定とその癌抑制効果2012

    • Author(s)
      矢野倉 恵
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
  • [Presentation] 専攻医教育プログラム 卵巣がん2012

    • Author(s)
      阪埜 浩司
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
  • [Presentation] 子宮体癌培養細胞株を用いたエピジェネティックに制御される癌抑制遺伝子として機能する microRNA の検索2010

    • Author(s)
      阪埜 浩司
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23

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Published: 2014-08-29  

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