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2012 Fiscal Year Final Research Report

Risk factors of associated with hearing impairment : an epidemiological study

Research Project

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Project/Area Number 22591873
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHirosaki University

Principal Investigator

SHINKAWA Hideichi  弘前大学, 医学(系)研究科(研究院), 教授 (90125584)

Co-Investigator(Kenkyū-buntansha) KAKEHATA Seiji  弘前大学, 医学(系)研究科(研究院), 准教授 (90261619)
NAMBA Atsushi  弘前大学, 医学部附属病院, 講師 (50361027)
SASAKI Akira  弘前大学, 医学部附属病院, 講師 (20451479)
NAKAJI Shigeyuki  弘前大学, 医学(系)研究科(研究院), 教授 (10192220)
Project Period (FY) 2010 – 2012
Keywords聴覚障害 / 大規模調査 / アンチエイジング / 動脈硬化 / 遺伝子変異
Research Abstract

In this study, we showed that hearing worsens with age, and this was especially obvious in males.
Our results suggested that vascular sclerosis and osteoporosisare risk factors associated with age related hearing impairment. High pulse wave velocity, a parameter of vascular sclerosis, was related to loss of hearing and decreasing of bone mineral density in females also caused hearing impairment.
We confirmed 13 GJB2 gene mutations in this study and also found that 39 of 597 participants (6.53%) were bearers of mutations known to cause hearing impairment.

  • Research Products

    (22 results)

All 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Coping behaviors in relation to depressive symptoms and suicidal ideation among middle-aged workers in Japan2012

    • Author(s)
      Sugawara N, Yasui-Furukori N, Sasaki G, Tanaka O, Umeda T, Takahashi I, Iwane K, Matsuzaka M, Kaneko S, Nakaji S
    • Journal Title

      J Affect Disord

      Volume: 142(1-3) Pages: 264-268

    • Peer Reviewed
  • [Journal Article] Relationships between suicidal ideation and the dimensions of depressive symptoms among middle-aged population in Japan2012

    • Author(s)
      Sugawara N, Yasui-Furukori N, Sasaki G, Umeda T, Takahashi I, Danjo K, Matsuzaka M, Kaneko S, Nakaji S
    • Journal Title

      J Affect Disord

      Volume: 136(3) Pages: 819-823

    • Peer Reviewed
  • [Journal Article] INFLUENCE OF TRACE ELEMENTS WITHIN NORMAL PHYSIOLOGICAL RANGE ON NEUTROPHIL BASAL REACTIVE OXYGEN SPECIES PRODUCTION IN THE JAPANESE GENERAL POPULATION2012

    • Author(s)
      伊藤 治幸, 高橋 一平, 松坂 方士, 李 相潤, 板井 一好, 福井 真司, 浜田 菜穂子, 齋藤 百合子, 梅田 孝, 中路 重之
    • Journal Title

      弘前医学

      Volume: 63(2-4) Pages: 85-95

    • Peer Reviewed
  • [Journal Article] AMH(抗ミューラー管ホルモン)と骨密度の関連性についての検討2012

    • Author(s)
      飯野 香理, 阿部 和弘, 柞木田 礼子, 谷口 綾亮, 樋口 毅, 水沼 英樹, 中路 重之
    • Journal Title

      Osteoporosis Japan

      Volume: 20(3) Pages: 485-486

    • Peer Reviewed
  • [Journal Article] 一般住民検診における腰椎疾患と末梢動脈疾患に関する疫学調査2012

    • Author(s)
      和田 簡一郎, 小野 睦, 田中 利弘, 石橋恭之, 藤 哲, 中路 重之
    • Journal Title

      Journal of Spine Research

      Volume: 3(6) Pages: 907-910

    • Peer Reviewed
  • [Journal Article] LIFESTYLE HAS SIGNIFICANT EFFECTS ON ATHEROSCLEROSIS IN THE POPULATION AS YOUNG AS BELOW 40 YEARS OLD2012

    • Author(s)
      岩間 孝暢, 檀上 和真, 松坂 方士, 高橋一平, 岩崎 宏貴, 渡邉 清誉, 大久保 礼由, 高橋 和幸, 梅田 孝, 中路 重之
    • Journal Title

      弘前医学

      Volume: 63(1) Pages: 55-65

    • Peer Reviewed
  • [Journal Article] EFFECTS OF CHANGES IN PHYSIQUE AND LIFESTYLE ON BONE MINERAL DENSITY IN THE EARLY TEENS2012

    • Author(s)
      小枝 周平, 高橋 一平, 梅田 孝, 松坂 方士, 澄川 幸志, 古川 照美, 平川 裕一,上谷 英史, 戸塚 学, 中路 重之
    • Journal Title

      弘前医学

      Volume: 63(1) Pages: 28-37

    • Peer Reviewed
  • [Journal Article] 児童・生徒の健康、体力と生活習慣の現状 青森県の児童・生徒における体組成・生活習慣が動脈硬化および骨密度に及ぼす影響2012

    • Author(s)
      高橋 一平, 松坂 方士, 岩根 かほり, 岩崎 宏貴, 佐々木 英嗣, 梅田 孝, 中路 重之
    • Journal Title

      日本臨床スポーツ医学会誌

      Volume: 20(2) Pages: 277-279

    • Peer Reviewed
  • [Journal Article] Hearing impairment and cognitive function among a community-dwelling population in Japan2011

    • Author(s)
      N Sugawara, A Sasaki, N Yasui-Furukori, S Kakehata, T Umeda, A Namba, S Nakaji,H Shinkawa S Kaneko
    • Journal Title

      Annals of General Psychiatry

      Volume: 10(1) Pages: 27

    • Peer Reviewed
  • [Journal Article] Medical problems and risk factors of metabolic syndrome among radiographic knee osteoarthritis patients in the Japanese general population2011

    • Author(s)
      Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
    • Journal Title

      J Orthop Sci

      Volume: 16(6) Pages: 704-709

    • Peer Reviewed
  • [Journal Article] Smoking habits and health-related quality of life in a rural Japanese population2011

    • Author(s)
      Funahashi K, Takahashi I, Danjo K, Matsuzaka M, Umeda T, Nakaji S
    • Journal Title

      Qual Life Res

      Volume: 20(2) Pages: 199-204

    • Peer Reviewed
  • [Journal Article] Ankle brachial pressure index as a marker of apathy in a community-dwelling2011

    • Author(s)
      Sugawara N, Yasui-Furukori N, Umeda T, Kaneda A, Sato Y, Takahashi I, Matsuzaka M, Danjo K, Nakaji S, Kaneko S
    • Journal Title

      population

      Volume: 26(4) Pages: 409-414

    • Peer Reviewed
  • [Journal Article] 一般住民を対象とした集団検診における FRAXの検討2011

    • Author(s)
      飯野香理, 阿部和弘, 柞木田礼子, 谷口綾亮, 樋口毅, 水沼英樹, 中路重之
    • Journal Title

      Osteoporosis Japan

      Volume: 19(3) Pages: 473-475

    • Peer Reviewed
  • [Journal Article] Prevalence of metabolic syndrome among patients with schizophrenia in Japan2010

    • Author(s)
      Sugawara N, Yasui-Furukori N, Sato Y, Umeda T, Kishida I, Yamashita H, Saito M, Furukori H, Nakagami T, Hatakeyama M, Nakaji S, Kaneko S.
    • Journal Title

      Schizophr Res

      Volume: 123(2) Pages: 244-250

    • Peer Reviewed
  • [Journal Article] Comparing the influences of age and disease on distortion in the clock drawing test in Japanese patients with schizophrenia2010

    • Author(s)
      Kaneda A, Yasui-Furukori N, Umeda T, Sugawara N, Tsuchimine S, Saito M, Sato Y, Furukori H, Takahashi I, Nakaji S, Kaneko S
    • Journal Title

      Am J Geriatr Psychiatry

      Volume: 18(10) Pages: 908-916

    • Peer Reviewed
  • [Journal Article] Clock drawing performance in a community-dwelling population : Normative data for Japanese subjects2010

    • Author(s)
      Sugawara N, Yasui-Furukori N, Umeda T, Sato Y, Kaneda A, Tsuchimine S, Saito M, Nakaji S, Kaneko S
    • Journal Title

      Aging Ment Health

      Volume: 14(5) Pages: 587-592

    • Peer Reviewed
  • [Journal Article] Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population2010

    • Author(s)
      Sugawara N, Yasui-Furukori N, Umeda T, Kaneda A, Sato Y, Takahashi I, Matsuzaka M, Danjo K, Nakaji S, Kaneko S
    • Journal Title

      BMC Psychiatry

      Volume: Vol.10 Pages: 46

    • Peer Reviewed
  • [Presentation] 一般住民における GJB2 遺伝子変異の検討2011

    • Author(s)
      南場淳司, 佐々木亮, 新川秀一
    • Organizer
      第21回日本耳科学会総会
    • Place of Presentation
      那覇市
    • Year and Date
      2011-11-24
  • [Presentation] 難聴と認知機能低下の関連性 岩木健康増進プロジェクトにおける一般地域住民での検討2011

    • Author(s)
      佐々木亮, 欠畑誠治, 南場淳司, 新川秀一
    • Organizer
      第56回日本聴覚医学会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-10-28
  • [Presentation] Epidemiological View of Digestive Cancers in Japan2010

    • Author(s)
      Shigeyuki Nakaji
    • Organizer
      中国北方消化器内視鏡・消化器病フォーラム
    • Place of Presentation
      中国瀋陽市(中国医科大学)
    • Year and Date
      2010-05-29
  • [Presentation] 骨密度と聴力との関連-岩木健康増進プロジェクトにおける検討-2010

    • Author(s)
      佐々木亮, 欠畑誠治, 南場淳司, 新川秀一
    • Organizer
      第111回日本耳鼻咽喉科学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2010-05-20
  • [Book] 最新!がん治療-予防~緩和ケアまですべてがわかる2011

    • Author(s)
      中路重之
    • Total Pages
      255
    • Publisher
      朝日新聞出版

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Published: 2014-08-29  

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