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2013 Fiscal Year Final Research Report

Signal transduction system of human olfactory receptor cells

Research Project

  • PDF
Project/Area Number 22591898
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMie University

Principal Investigator

KOBAYASHI Masayoshi  三重大学, 医学(系)研究科(研究院), 准教授 (80343218)

Co-Investigator(Kenkyū-buntansha) KURAHASHI Takashi  大阪大学, 大学院生命機能研究科, 教授 (90225251)
TAKEUCHI Hiroko  大阪大学, 大学院生命機能研究科, 准教授 (10324823)
YAMAMOTO Tetsuro  三重大学, 大学院医学系研究科, 特任教授 (00127002)
TAKEUCHI Kazuhiko  三重大学, 大学院医学系研究科, 教授 (50206942)
TAMARI Kengo  三重大学, 医学部, 助教 (90585176)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords嗅覚 / 嗅細胞 / ヒト / パッチクランプ / 免疫染色
Research Abstract

To reveal signal transduction system of human olfactory receptor cells, we tried to record membrane potential of the olfactory receptor cells obtained from human using whole cell patch clamp method. We succeeded to record membrane potential of human olfactory receptor cells using the method and found that characteristics of the human olfactory receptor cells are similar to those of other animals that were reported previously.

  • Research Products

    (7 results)

All 2013 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Suppression and recovery of voltage-gated currents after cocaine treatments of olfactory receptor cells2013

    • Author(s)
      Tamari K, Takeuchi H, Kobayashi M,Kurahashi T, Yamamoto T
    • Journal Title

      Auris Nasus Larynx

      Volume: 40 Pages: 66-70

    • DOI

      10.1016/j.anl.2011.11.002

    • Peer Reviewed
  • [Journal Article] 局所麻酔薬コカイン投与時の嗅細胞膜電流変化2010

    • Author(s)
      玉利健悟 竹内裕子 小林正佳 倉橋隆 山本哲朗
    • Journal Title

      日本味と匂学会誌

      Volume: 17 Pages: 427-430

    • Peer Reviewed
  • [Presentation] Effects of cocaine on the olfactory receptor cell function2011

    • Author(s)
      Tamari K, Takeuchi H, Kobayashi M,Kurahashi T, Yamamoto T
    • Organizer
      Association for Chemoreception Sciences (AChemS)
    • Place of Presentation
      St. Pete Beach, Fl, USA
    • Year and Date
      2011-04-15
  • [Presentation] 局所麻酔薬コカイン投与時の嗅細胞膜電流変化2010

    • Author(s)
      玉利健悟 竹内裕子 小林正佳 倉橋隆 山本哲朗
    • Organizer
      日本味と匂学会第44回大会
    • Place of Presentation
      北九州市
    • Year and Date
      20100908-10
  • [Presentation] 嗅細胞の膜電流に対する塩酸コカインの影響2010

    • Author(s)
      小林正佳 玉利健悟 竹内裕子 倉橋隆 山本哲朗 西田幸平 竹内万彦
    • Organizer
      第141回日本耳鼻咽喉科学会東海地方部会連合講演会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-06-06
  • [Presentation] 塩酸コカインによる嗅細胞のNa+電流の抑制作用と安全性の検討2010

    • Author(s)
      小林正佳 玉利健悟 竹内裕子 倉橋隆 山本哲朗 西田幸平 竹内万彦
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台市
    • Year and Date
      2010-05-22
  • [Presentation] 嗅細胞の膜電流に対する塩酸コカインの影響2010

    • Author(s)
      玉利健悟 竹内裕子 小林正佳 倉橋隆 山本哲朗
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      日盛岡市
    • Year and Date
      2010-05-21

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Published: 2015-07-16  

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