The study of pathogenesis and related molecules of IgG4 related disease and development of treatment modality.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591905
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Yamagata University
• Principal Investigator: OHTA Nobuo 山形大学, 医学部, 講師 (20282212)
• Co-Investigator(Kenkyū-buntansha): KURAKAMI Kazuya 山形大学, 医学部, 助教 (30571640) ; FURUKAWA Takatoshi 山形大学, 医学部, 助教 (80466630) ; SUZUKI Yusuke 山形大学, 医学部, 助教 (50466629) ; KUBOTA Toshinori 山形大学, 医学部, 助教 (80536954)
• Project Period (FY): 2010 – 2012
• Keywords: IgG4関連疾患 / ペリオスチン / Th17 / Th1 / Tc1

Research Abstract

IgG4-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or IL-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. Our findings revealed a predominance of Th1 and Tc1 cells and overexpression of IL-17 in patients with IgG4-related sclerosing sialadenitis. This observation emphasizes the involvement of Th1 and Tc1 cells and IL-17 in the pathogenesis of this disease. Identify their precise functional properties would greatly enhance our understanding of their pathogenetic roles. A detailed phenotypic and functional analysis of these subsets is warranted.

Research Products

• [Journal Article] Clinical and pathological characteristics of organized hematoma (2013)
  • Author(s): Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A, Aoyagi M, Matsubara A, Izuhara K, Kakehata K
  • Journal Title: Int. J Otolaryngology
  • Peer Reviewed
• [Journal Article] Clinicopathological characteristics of IgG4-related sclerosing sialadenitis (2012)
  • Author(s): Ohta N, Kurakami K, Ishida A, Furukawa T, et al
  • Journal Title: Laryngoscope Volume: 122 Pages: 572-577
  • Peer Reviewed
• [Journal Article] The roles of IL-17 and Th1 and Tc1 cells in patients with IgG4-related sclerosing sialadenitis Laryngoscope (2012)
  • Author(s): Ohta N, Makihara S, Okano M, Kurakami K, Ishida A, Furukawa T, Suzuki Y, et al
  • Volume: 122
  • Pages: 2169-2174
  • Peer Reviewed
• [Journal Article] NMDAreceptor-mediated Ca(2+) influxtriggers nucleoctoplasmictranslocation of diacylglycerol kinaseζ under oxygen-glucose deprivationconditions, an in vitro model of ischemia, in rat hippocampal slices (2012)
  • Author(s): Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fuji S, Goto K
  • Journal Title: Histchem Cell Biol Volume: 137 Pages: 499-511
  • Peer Reviewed
• [Journal Article] Expression of Pendrin and Periostin in Allergic Chronic Rhinosinusitis (2012)
  • Author(s): Ishida A, Ohta N, Suzuki Y, Kakehata S, Okubo K, Ikeda H, Shiraishi H, Izuhara K
  • Journal Title: Allergology Int. Volume: 61(4) Pages: 589-595
  • Peer Reviewed
• [Journal Article] IgA production and tonsillar focal infection in IgA nephropathy (2012)
  • Author(s): Meng H, Ohtake H, Ishida A, Ohta N, Kakehata S, Yamakawa M.
  • Journal Title: J Clin Exp Hematop Volume: 52(3) Pages: 161-70
  • Peer Reviewed
• [Journal Article] The role of periostin in eosinophilic otitis media (2012)
  • Author(s): Nishizawa K, Matsubara A, Nakagawa T, Ohta N, Izuhara K, Shinkawa H
  • Journal Title: Acta Otolaryngol Volume: 132 Pages: 838-844
  • Peer Reviewed
• [Journal Article] IgG4関連疾患その最新の知見について (2012)
  • Author(s): 倉上和也 ,太田伸男 ,欠畑誠治
  • Journal Title: 耳鼻免疫アレルギー Volume: 30 Pages: 9-14
  • Peer Reviewed
• [Journal Article] 唾液腺導管癌を合併したIgG4関連硬化性疾患の1例 (2011)
  • Author(s): 倉上和也, 他
  • Journal Title: 耳鼻臨床 Volume: 130 Pages: 158-162
  • Peer Reviewed
• [Presentation] IgG4関連硬化性疾患背線維化に関する検討 (2013)
  • Author(s): 太田伸男,倉上和也,古川孝俊,鈴木祐輔,櫻井真一,稲村和俊,石田晃弘,欠畑誠治
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷市芸文館,倉敷
  • Year and Date: 2013-02-09
• [Presentation] IgG4関連疾患への悪性腫瘍合併に関する検討 (2013)
  • Author(s): 倉上和也,太田伸男,石田晃弘,稲村和俊,鈴木祐輔,古川孝俊,欠畑誠治
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷市芸文館,倉敷
  • Year and Date: 2013-02-09
• [Presentation] IgG4関連硬化性疾患患者におけるぺリオスチンおよび TGF-betaの発現 (2012)
  • Author(s): 太田伸男 ,倉上和也,鈴木祐輔 ,石田晃弘 ,和気貴祥 ,出原賢治
  • Organizer: 第62回日本アレルギー学会
  • Place of Presentation: 大阪国際会議場 ,大阪
  • Year and Date: 2012-11-30
• [Presentation] IgG4-related sialadenitis. Pearls and pitfalls in management (2012)
  • Author(s): Ohta N, Kurakami K, Suzuki Y, Ishida A, Kakehata S
  • Organizer: American academy of Otolaryngology-Head and Neck surgery Annual meeting
  • Place of Presentation: Convention Center, Washington DC, USA
  • Year and Date: 2012-09-11
• [Presentation] IgG4関連硬化性疾患患者のTh1,Th2,Tc1,Tc2細胞および IL-17 (2012)
  • Author(s): 太田伸男,倉上和也 ,牧原靖一郎 ,岡野光博 ,石田晃弘,鈴木祐輔,欠畑誠治
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 琵琶湖ホテル ,大津
  • Year and Date: 2012-02-18
• [Presentation] IgG4関連疾患の合併症に関する検討 (2012)
  • Author(s): 倉上和也,太田伸男,石田晃弘,稲村和俊 ,鈴木祐輔 ,古川孝俊 ,欠畑誠治
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 琵琶湖ホテル ,大津
  • Year and Date: 2012-02-18
• [Presentation] IgG4関連硬化性疾患とEpstein-Barr virus感染との関連性についての検討 (2012)
  • Author(s): 古川孝俊 ,太田伸男,石田晃弘,倉上和也 ,欠畑誠治
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 琵琶湖ホテル ,大津
  • Year and Date: 2012-02-18
• [Presentation] ミニシンポジウムIgG4関連硬化性疾患患者における Th1,Th2,Tc1,Tc2細胞および IL-17の役割 (2011)
  • Author(s): 太田伸男
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 新高輪国際パミール館 ,東京
  • Year and Date: 2011-11-12