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2012 Fiscal Year Final Research Report

Neuroprotective effect of an antioxidant, lutein in the retina of a murine model of diabetes.

Research Project

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Project/Area Number 22591950
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

SASAKI Mariko  慶應義塾大学, 医学部, 特任助教 (60276342)

Co-Investigator(Kenkyū-buntansha) OZAWA Yoko  慶應義塾大学, 医学部, 講師 (90265885)
Project Period (FY) 2010 – 2012
Keywords網膜神経保護 / 抗酸化剤 / ルテイン / 糖尿病 / 網膜神経変性
Research Abstract

Diabetic retinopathy is a progressive neurodegenerative disease, but the underlying mechanism is still obscure. Here, we focused on oxidative stress in the retina, and analysed its influence on retinal neurodegeneration, using an antioxidant, lutein. Lute

  • Research Products

    (5 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Neuroprotective effects of lutein in the retina.2012

    • Author(s)
      Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K
    • Journal Title

      Curr Pharm Des

      Volume: 18(1) Pages: 51-6

    • Peer Reviewed
  • [Journal Article] Neural degeneration in the retina of the streptozotocin-induced type 1 diabetes model.2011

    • Author(s)
      Ozawa Y, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K. Exp Diabetes Res.
    • Journal Title

      Epub 2011

      Volume: Nov 17 Pages: 108328

    • Peer Reviewed
  • [Journal Article] Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes.2010

    • Author(s)
      Sasaki M, Ozawa Y, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K.
    • Journal Title

      Diabetologia

      Volume: 53(5) Pages: 971-9

    • Peer Reviewed
  • [Presentation] Neuroprptective effect of an antioxidant lutein in the diabetic retina2011

    • Author(s)
      Sasaki M, Yuki K, Kubota S, Miyake S, Kobayashi S, Ishida S, Tsubota K, Ozawa Y
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2011-05-02
  • [Remarks]

    • URL

      http://www.keio-eye.net

URL: 

Published: 2014-08-29  

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