2012 Fiscal Year Final Research Report
Development of intestinal regeneration in vivo using polyglycolic acid felt as a extracellular matrix.
| Project/Area Number |
22591983
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KIMURA Osamu 京都府立医科大学, 医学研究科, 助教 (10315963)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Taizo 京都府立医科大学, 医学研究科, 助教 (20515291)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小腸機能不全 / 小腸再生 / 神経ペプチド / ポリグリコール酸フェルト / 胎児肺低形成 / 肺再生治療 |
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| Research Abstract |
The aim of this study was intestinal regeneration using neuropeptide bombesin in rats. But it was elucidated that administration of bombesin was not enough to regenerate muscle layer properly with normal mucosal structure. Because of the limit of time and cost, we changed the purpose of this project from intestinal regeneration to lung regeneration with the same neuropeptide using CDH rat model.Using pregnant Sprague-Dawley (SD) rat(term22) which received 100mg of nitrofen into stomach through nasogastric tube on day 9.5, it was found that lung weight to body weight ratio(LW/BW) in CDH rat increases bombesin dose-dependently.
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