Visualization of the thermal energy change and the metabolism change in the body during sepsis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kyoto University (2011-2012); Nippon Medical School (2010)
• Principal Investigator: SATO Norio 京都大学, 大学院・医学研究科, 講師 (30409205)
• Co-Investigator(Kenkyū-buntansha): HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162) ; KOIKE Kaoru 京都大学, 大学院・医学研究科, 教授 (10267164) ; SUZUKI Takao 京都大学, 大学院・医学研究科, 講師 (40328810)
• Project Period (FY): 2010 – 2012
• Keywords: 敗血症 / 代謝動態 / 免疫調整栄養剤 / ホエイプロテイン / n-3系脂肪酸

Research Abstract

Sepsis is systemic inflammatory response syndrome (SIRS) caused by infection. Energy metabolism is remarkably aggravated and hyper catabolism resulted in protein breakdown. It is important to understand metabolic change in liver and muscle which are mainly related heat production. Nutrition is expected to suppress inflammatory reaction and improve metabolic changes. We successfully demonstrated metabolic changes between immune-modulating diet and control diet under septic insult using nuclear magnetic resonance.