2012 Fiscal Year Final Research Report
The Role of osteoactivin on the function of periodontal tissues
| Project/Area Number |
22592043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
GOTO Tetsuya 九州歯科大学, 歯学部, 准教授 (70253458)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Shigeru 九州歯科大学, 歯学部, 教授 (10118078)
KATAOKA Shinji 九州歯科大学, 歯学部, 助教 (80364149)
KUROISHI Kayoko 九州歯科大学, 歯学部, 助教 (60468303)
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| Project Period (FY) |
2010 – 2012
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| Keywords | RT-PCR / オステオアクチビン / 免疫染色 / 歯周組織 / 歯根膜細胞 / 歯牙移動 / 破骨細胞 / 骨芽細胞 |
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| Research Abstract |
During the orthodontic tooth movement, on the pressure sidebone resorption occurs, while on the tension side bone formation is accelerated.However, the mechanism of the activation for bone formation at the tension side isunknown. We hypothesized that osteoactivin (OA) may be involved in the activation ofbone formation at the tension side, we examined the expression or activation of OA at the tension side. The results of this study indicated that ADAMs, which may inducethe activation of osteoblastic bone formation on the alveolar bone, sheds the Oaexpressed in the periodontal ligamental cells at the tension side.
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