2012 Fiscal Year Final Research Report
A possible role of glucose transporters and monocarboxylate transporters in osteocytes during changes of extracellular milieus
| Project/Area Number |
22592045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IRIE Kazuharu 北海道医療大学, 歯学部, 教授 (70223352)
SHIBUI Toru 北海道医療大学, 歯学部, 助教 (80453265)
TAKAHASHI Masami 北海道医療大学, 歯学部, 助教 (50550307)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨芽細胞 / 骨細胞 / 軟骨細胞 / 低酸素応答因子 / ルコース輸送担体 / モノカルボン酸輸送担体 |
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| Research Abstract |
In alveolar bone of mouse mandibular bone, the structure of lamellar bone newly formed after bone remodeling was clearly different from that of older bone. It was observed by phalloidin stainingthat the network of bone canaliculi was not connected between the new bone and older bone. Osteocytes in the old bone showed positive staining of HIF-1α, HIF-2α, GLUT3 and MCT2, whereas those in the new bone was not stained. We conclude that osteocytes survive in a severe milieus through expression of HIFs, GLUTs and MCTs.
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