A novel bisphosphonate with potent anabolic action for periodontitis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: SHINODA Hisashi 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (80014025)
• Co-Investigator(Kenkyū-buntansha): IGARASHI Kaoru 東北大学, 大学院・歯学研究科, 教授 (70202851) ; MURAKAMI Shinobu 東北大学, 大学院・歯学研究科, 大学院非常 勤講師 (40436093) ; CHIBA Mirei 東北大学, 大学院・歯学研究科, 講師 (10236820) ; SUZUKI Keiko 昭和大学, 歯学部, 講師 (50119187)
• Project Period (FY): 2010 – 2012
• Keywords: ビスホスホネート / 歯周病 / 骨形成 / 骨吸収 / NF-κB

Research Abstract

The current study was carried out to investigate by what mechanism a novel bisphosphonate, [4-(methylthio) phenylthio] methanebisphosphonate (MPMBP), can promote bone formation, and whether this compound can be effective on the periodontitis. Our results show that MPMBP promotes the expression of mRNA that relates osteogenesis, and that this compound was effective on the experimental periodontitis in rats and dogs. MPMBP may be used not only for the treatment of periodontitis, but also for various conditions that require the regeneration of bone tissues.

Research Products

• [Journal Article] Effect of bisphosphonate on osteoclastogenesis in RAW264.7 cells (2012)
  • Author(s): Abe K, Yoshimura Y, Deyama Y, Kikuiri T, Hasegawa T, Tei K, Shinoda H, Suzuki K, Kitagawa Y
  • Journal Title: InternationalJournal of Molecular Medicine Volume: 29巻 Pages: 1007-1015
  • DOI: DOI:10.3892/ijmm2012.952
  • Peer Reviewed
• [Journal Article] 新規ビスフォスホネート[4-(methylthio) phenylthio] methane-bisphosphonateのanabolicな作用 (2011)
  • Author(s): 鳴澤祐香、千葉美麗、鈴木恵子、村上忍、竹山禎章、山田章司、五十嵐薫、篠田壽
  • Journal Title: Clinical Calcium Volume: 21巻 Pages: 116-117
• [Journal Article] Effects of mevastatin on grafted bone in MRL/MpJ mice (2010)
  • Author(s): Sugazaki M, Hirotani S, Takeyama S, Shinoda H
  • Journal Title: Connective Tissue Research Volume: 51巻 Pages: 105-112
  • DOI: DOI:10.3109/03008200903105098
  • Peer Reviewed
• [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs calvarial and alveolar bone in vivo (2013)
  • Author(s): Suzuki K, Arimoto T, Morohashi T, Sakai N, Karakawa A, Shinoda H, Yamada S
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan(Italy)
  • Year and Date: 2013-08-23
• [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs alveolar bone in rats (2011)
  • Author(s): Yano A, Suzuki K, Morohashi T, Arimoto T, Karakawa A, Igarashi T, Shinoda H, Yamamoto M, Yamada S
  • Organizer: Annual Meeting for theAmerican Society for Bone and Mineral Research
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2011-09-17
• [Presentation] 新規ビスフォスホネート[4-(methylthio)phenylthio]methanebis-phosphonate]のanabolicな作用 (2011)
  • Author(s): 鳴澤祐香、千葉美麗、鈴木恵子、村上忍、竹山禎章、山田章司、五十嵐薫、篠田壽
  • Organizer: 第32回東北骨代謝研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-05
• [Presentation] Anabolicな作用をもつ新規ビスホスホネート[4-(methylthio)phenylthio]methanebisphosphonate]の作用機序 (2010)
  • Author(s): 鳴澤祐香、千葉美麗、鈴木恵子、村上忍、竹山禎章、山田章司、五十嵐薫、篠田壽
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 20100920-22
• [Presentation] In vvoimaging of osteoclast precursor recruitment to the iInflammatory site where extensive bone destruction occurs (2010)
  • Author(s): Suzuki K, Takeshita F, Yamamoto K, Yamada S, Shinoda H, Ochiya T
  • Organizer: Annual Meeting for the American Society for Bone and Mineral Research
  • Place of Presentation: Toronto (Canada)
  • Year and Date: 2010-09-17
• [Presentation] Structure-activity relationships of bisphosphonates with respect to their effect on the LPS-induced increase in the synthesisof prostaglandin E2 and nitric oxide (2010)
  • Author(s): Shinoda H, Murakami S, Suzuki K, Chiba M, Takeyama S, Narusawa Y, Hirotani H, Yamada S, Igarashi K, Stern PH
  • Organizer: Annual Meeting for the AmericanSociety for Bone and Mineral Research
  • Place of Presentation: Toronto (Canada)
  • Year and Date: 2010-09-16
• [Presentation] A novel bispho sphonate with potent anabolic action (2010)
  • Author(s): Shinoda H, Suzuki K, Chiba M, Murakami S, Takeyama S, Narusawa Y, Hirotani H, Yamada S, Igarashi K, Stern PH
  • Organizer: Annual Meeting for the American Society for Bone and Mineral Research
  • Place of Presentation: Toronto (Canada)
  • Year and Date: 2010-09-15