2012 Fiscal Year Final Research Report
A new regulative mechanism for monoamine transporter expression in plasma membrane : The participation of histamine H3 receptor
| Project/Area Number |
22592065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
SOGAWA Norio 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (30236153)
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| Co-Investigator(Kenkyū-buntansha) |
OHYAMA Kazumi 岡山大学, 大学院・医歯薬学総合研究科, 助手 (00253021)
SOGAWA Chiharu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10253022)
MIYAZAKI Ikuko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40335633)
KITAYAMA Shigeo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (80177873)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ヒスタミン H3 受容体(H3R) / モノアミントランスポーター / ノルアドレナリントランスポーター(NET) |
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| Research Abstract |
To study the participation of histamine H3 receptor (H3R) on the transition of monoamine transporters into plasma membrane which is necessary to exert their function as transporters, we investigated the relation between H3R and noradrenaline transporter (NET) expression by using coexpressing cell system for both H3R and NET. The results which obtained from this experiment were suggested that there was a mechanism by which H3R inhibited the NET expression into the plasma membrane by binding to NET and making it fit tightly in the cell.
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