2012 Fiscal Year Final Research Report
Elucidation of molecular mechanisms of osteoclastogenesis by iron
| Project/Area Number |
22592069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAKAI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10176612)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKUBA Takayuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30264055)
OKAMOTO Kuniaki 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10311846)
NISHISHITA Kazuhisa 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20237697)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨代謝 / 破骨細胞 / 酸化ストレス / ポリフェノール |
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| Research Abstract |
We reported that RANKL-induced suppression of heme oxygenase-1 (HO-1), a heme-degrading enzyme, promoted caspase3 activation and HMGB1 release during osteoclastogenesis. Induction of HO-1 by tBHQ or polyphenol such as kahweol and fisetin inhibited osteoclastogenesis respectively. Since transcriptional induction of HO-1 is up-regulated by Nrf2, we studied the effect of Nrf2 on osteoclastogenesis. Studies with Nrf2 KO mice bone marrow macrophages showed enhanced formation of osteoclasts compared with wild type mice bone marrow macrophages.
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