• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Roles of expressions of estrogen receptor against ROS production in estrogen-dependent diseases

Research Project

  • PDF
Project/Area Number 22592094
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKagoshima University

Principal Investigator

SUENAGA Shigeaki  鹿児島大学, 医学部・歯学部附属病院, 講師 (00136889)

Co-Investigator(Kenkyū-buntansha) INDO Hiroko  鹿児島大学, 医歯学総合研究科, 助教 (00301391)
TOMITA Kazuo  鹿児島大学, 医歯学総合研究科, 助教 (60347094)
MAJIMA Hideyuki  鹿児島大学, 医歯学総合研究科, 教授 (60165701)
Project Period (FY) 2010 – 2012
Keywords活性酸素 / エストロゲン / エストロゲンレセプター / ミトコンドリア / 過酸化脂質 / アポトーシス / アンチオキシダント効果 / オキシダント効果
Research Abstract

We examined the expressions of estrogen receptor, the production and activity of mitochondrial reactive oxygen species (ROS), lipid peroxidation and apoptosis following a cytokine plus estrogen (dose: 10-10M~10-4M) treatment in human normal fibroblasts, RA fibroblasts, VA-13, MCF-7, and MDA-MB453 cells. The oxidant and anti-oxidant effects of estrogen on the ROS generation, lipid peroxidation product, and subsequent apoptotic cell death depended on cell types, expressions of estrogen receptor (α, β), doses of estrogen.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line2012

    • Author(s)
      Indo HP, Inanami O, Koumura T, Suenaga S, et al
    • Journal Title

      Free Radic Res

      Volume: 46 Pages: 1029-1043

    • DOI

      DOI:10.3109/10715762.2012.698012

    • Peer Reviewed
  • [Journal Article] Mitochondria as possible pharmaceutical targets for the effects of vitamin E and its homologues in oxidative stress-related diseases2011

    • Author(s)
      Majima HJ, Indo HP, Suenaga S, Matsui H, Yen H-C, Ozawa T
    • Journal Title

      Curr Pharm Des

      Volume: 17 Pages: 2190-2195

    • DOI

      DOI:10.2174/138161211796957490

    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌における所属リンパ節転移の画像診断精度-造影CT、USおよびPETによる評価-2012

    • Author(s)
      末永重明、犬童寛子、川畑義裕、河野一典、佐藤強志、比地岡浩志、中村典史、仙波伊知郎、馬嶋秀行
    • Organizer
      日本歯科放射線学会 第53回学術大会
    • Place of Presentation
      盛岡
    • Year and Date
      20120601-03
  • [Presentation] Induction of mitochondrial ROS and cell death by cytokines and its prevention by estrogen in rheumatoid arthritis fibroblasts2011

    • Author(s)
      Suenaga S, Indo HP, Yen H-C, Ijiri K, Komiya S, Matsuyama T, Higuchi M, Matsui H, Ozawa T, Majima HJ
    • Organizer
      5thSFRR-Asia, 8thASMRM, 11thJ-mit 2011
    • Place of Presentation
      Kagoshima
    • Year and Date
      20110831-0904
  • [Presentation] Nitric- and oxidative mitochondria related cell death by cytokines and its prevention by estrogen in estrogen receptor expressed rheumatoid arthritis synovial fibroblasts2010

    • Author(s)
      Suenaga S, Indo HP, Tomita K, Ijiri K,Komiya S, Yen H-C, Higuchi M, MatsuiH., Ozawa T, Majima HJ
    • Organizer
      The 6thInternational Conference Biology,Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto
    • Year and Date
      20100614-18

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi