2012 Fiscal Year Final Research Report
Clarification of pathogenic mechanism of PCR and development of the prevention method -a study with rat mandibular distraction model-
| Project/Area Number |
22592208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Naoya 新潟大学, 医歯学総合病院, 助教 (10361908)
KOJIMA Taku 新潟大学, 医歯学系, 助教 (90515777)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Kayoko (NOZAWA Kayoko) 新潟大学, 医歯学系, 特任准教授 (90303130)
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| Project Period (FY) |
2010 – 2012
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| Keywords | PCR / 発症メカニズム / 下顎骨延長 / ラット実験モデル / マイクロ CT |
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| Research Abstract |
This study was undertaken to examine the effects of mechanical loadings on the morphology of mandibular condyle following distraction in rat experimental model.10-week-old male Wistar rats received 3.5 mm unilateral mandibular distraction over 10 days after5-day latency period, and the morphological changes of mandibular condyles were examined one day, one week and three weeks after distraction. As a result, the deformation of the condyle with a destruction of cartilage layer and a bone resorption was recognized. These findings indicate thatoverloading to the mandibular condyle is a key factor for PCR.
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