2012 Fiscal Year Final Research Report
Development of the very functional biomaterial that possess theability of the control of the drug delivery system.
| Project/Area Number |
22592216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKECHI Masaaki 広島大学, 医歯薬保健学研究院, 准教授 (00304535)
NAKAGAWA Takayuki 広島大学, 病院, 病院助教 (30456230)
KAMATA Nobuyuki 広島大学, 医歯薬保健学研究院, 教授 (70242211)
TADA Misato 広島大学, 病院, 助教 (40572326)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 顎骨骨髄炎 / 高機能性薬物徐放担体 |
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| Research Abstract |
lf a superior bone filling material were to be developed that allowed high concentrations of antibiotics that acted only locally, and allowed bone formation at the same time, an ideal method of treating osteomyelitis would become available. We created an implant composed of poly(L-lactic acid)(PLLA)and poly(DL-lactic-co-glycolic acid)(PLGA),gentamicin, and α-TCP or β-TCP. The results of sustained-release testing in vivo and in vitro demonstrated the release of effective antibiotic concentrations over 5-month period. Further, when an experimental model of osteomyelitis was produced in rabbits and the implant was inserted after bone marrow curettage, the implant proved effective in preventing the progression of osteomyelitis and in achieving local bone formation.
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[Journal Article] A case of SAPHO syndrome with diffuse sclerosing osteomyelitis of the mandible treated successfully with prednisolone and bisphosphonate2012
Author(s)
Hatano, H., Shigeishi, H., Higashikawa, K., Shimasue, H., Nishi, H., Oiwa, H., Shindo, H., Takechi, M., Ohge, H. and Kamata, N
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Journal Title
J Oral Maxillofac Surg.
Volume: 70
Pages: 626-631
Peer Reviewed
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[Journal Article] 3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering2012
Author(s)
Takechi, M., Ohta, K., Ninomiya, Y., Tada, M., Minami, M., Takamoto, M., Ohta, A., Nakagawa, T., Fukui, A.,Miyamoto, Y, and Kamata, N
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Journal Title
Dental Materials Journal
Volume: 31(3)
Pages: 465-471
Peer Reviewed
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[Journal Article] Clinical evaluation of novel interconnected porous hydroxyapatite ceramics (IP-CHA) in a maxillary sinus floor augmentation procedure.2012
Author(s)
Shigeishi,H.,Takechi,M..,Nishimura, M., Takamoto ,M., Minami, M., Ohta, K., and Kamata, N.
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Journal Title
Dental Materials Journal
Volume: 31(1)
Pages: 54-60
Peer Reviewed
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