2012 Fiscal Year Final Research Report
Clinical analysis of Odontogenic tumors and Development of genetherapy using RNAi and anti-sense methods.
| Project/Area Number |
22592220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yasutaka 九州大学, 大学病院, 講師 (60205151)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯原性腫瘍 / アンチセンス / 角化嚢胞性歯原性腫瘍 / RNAi / 遺伝子治療 |
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| Research Abstract |
It is strongly suggested that interleukin-1α(IL-1α) and keratinocyte growth factor(KGF) may play an essential role in regulating the odontogenic tumor growth within the jaw. The volume of marsupialised keratocystic odontogenic tumors was reduced by half over a 239 day cycle. For the new therapy of odontogenic tumors, we are testing the effect of anti-sense methods.
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