2012 Fiscal Year Final Research Report
Analysis of microRNA in temporomandibular joint inflammation
| Project/Area Number |
22592230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Naomi 日本大学, 松戸歯学部, 講師 (10152448)
AKUTSU Miwa 日本大学, 松戸歯学部, 助教 (10523524)
ITO Ko 日本大学, 松戸歯学部, 助教 (20419758)
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| Research Collaborator |
KAWASHIMA Mutsumi 日本大学, 松戸歯学部, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | 顎関節 / 滑膜炎 / 滑膜細胞 / microRNA / マイクロアレイ解析 / interluekin-1β / tumor necrosis factor-α |
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| Research Abstract |
MicroRNA (miRNA) are a class of small non-coding RNAs that mediate the post-transcriptional regulation of target mRNA expression. miRNA are associated with pathologic conditions. We have investigated of IL-1β or TNF-α-responsive miRNA and mRNA in synoviocytes for putative genes associated with the synovitis using microarray analysis. The target genes for IL-1β? and/or TNF-α?responsive miRNA were searched by the databases such as TargetScan. The expressions of the target genes were analyzed by DNA microarray. The knowledge of miRNA-miRNA studies would help to understand the pathologic conditions in TMJ.
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