2012 Fiscal Year Final Research Report
Signaling pathway analysis of hypoxia-related gene and clock geneDEC in gingival inflammation
| Project/Area Number |
22592232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University (2011-2012)
Kanagawa Dental College (2010) |
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Principal Investigator |
ITO Yumi 鶴見大学, 歯学部, 講師 (00176372)
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| Co-Investigator(Kenkyū-buntansha) |
BHAWAL Ujjal 日本大学, 松戸歯学部, 助教 (50433339)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 炎症 / 低酸素関連遺伝子 / 時計遺伝子 / シグナル伝達 |
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| Research Abstract |
The aim of this study was to examine the expression of hypoxia responsive gene and clock gene DEC1 in gingival inflammation. We demonstrate that the pro-inflammatory cytokine interleukin-1β (IL-1β) up-regulated DEC1 and hypoxia-inducible factor-1α (HIF-1α) protein and elevated the HIF-1α-responsive gene vascular endothelial growth factor (VEGF) expression in human primary gingival cells. Furthermore, we clarify the signaling pathways (NF-kB, COX-2, and PI-3K-Akt) involved in the regulation of IL-1β-mediated DEC1 protein expression.
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Author(s)
Kuboyama N, Kiba H, Arai K, Uchida R, Tanimoto Y, Bhawal UK, Abiko Y, Miyamoto S, Knight D, Asakura T, Nishiyama N
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Journal Title
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[Journal Article] IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway2012
Author(s)
Bhawal UK, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, Sasahira T, Hamada N, Kuniyasu H, Arakawa H, Kato Y, Abiko Y
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Journal of Cellular Biochemistry
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[Journal Article] The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer2012
Author(s)
Wu Y, Sato F, Yamada T, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, Morohashi S, Hakamada K, Abiko Y, Kato Y, Kijima H
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Journal Title
International Journal ofOncology
Volume: 41(4)
Pages: 1337-1346
DOI
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[Journal Article] The basic helix-loop-helix transcription factor DEC2 inhibitsTGF-β-induced tumor progression in humanpancreatic cancer BxPC-3 cells2012
Author(s)
Sato F, Kawamura H, Wu Y, Sato H, Jin D, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, Morohashi S, Kato Y, Kijima H
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Journal Title
International Journal of Molecular Medicine
Volume: 30(3)
Pages: 495-501
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[Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver2012
Author(s)
Sato F, Sato H, Jin D, Bhawal UK, Wu Y, NoshiroM, Kawamoto T, Fujimoto K, SeinoH, Morohashi S, Kato Y, Kijima H
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Journal Title
Biochemical Biophysics ResearchCommunication
Volume: 419(2)
Pages: 441-446
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[Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingivalinflammation2012
Author(s)
Ito Y, Bhawal UK, Sasahira T, Toyama T, Sato T, Matsuda D, Nishikiori H, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H
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Journal Title
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Pages: 73-80
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[Journal Article]2011
Author(s)
Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kijima H, Kuniyasu H, Abiko Y, Kato Y, Sato S
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Journal Title
Journal of Pathology
Volume: 224(3)
Pages: 420-429
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