2012 Fiscal Year Final Research Report
The study detects the prognosis and metastatic markers of oral cancer by imaging mass spectrometry and develops the molecular pathology diagnostic procedure
| Project/Area Number |
22592238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
NAGATA Tetsuji 浜松医科大学, 医学部附属病院, 講師 (60264058)
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| Co-Investigator(Kenkyū-buntansha) |
SETOU Mitsutoshi 浜松医科大学, 医学部, 教授 (20302664)
KURABE Nobuya 浜松医科大学, 医学部, 助教 (60466737)
ONODERA Makiko 北海道大学, 大学病院, 医員 (20443963)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床腫瘍学 |
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| Research Abstract |
In this study, we tried to clearly distinguish the border based on the biomolecule distributions visualized by imaging mass spectrometry (IMS) analysis. Two signals at m/z 770 and m/z 846 were distributed on each region and showed a clear border. A tandem mass spectrometry analysis identified these signals as phosphatidylcholine (PC) (16:0/16:1) at m/z 770 on the cancer region and PC (18:1/20:4) at m/z 846 on the stroma region. In conclusion, the cancer region and stromal region of OSCCs were clearly distinguished with the use of these PC species by IMS analysis and the mo lecular identification can provide important information to elucidate the mechanism in cancer invasion.
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