Establishment of the new diagnostic procedure of oral cancer whichtargeted midkine and development of the therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: OTA Kazutoshi 熊本大学, 医学部附属病院, 講師 (20336209)
• Co-Investigator(Kenkyū-buntansha): SHINOHARA Masanori 熊本大学, 生命科学研究部, 教授 (90117127) ; ANDO Yukio 熊本大学, 生命科学研究部, 教授 (20253742)
• Project Period (FY): 2010 – 2012
• Keywords: 臨床腫瘍学 / ミッドカイン / 口腔癌 / 腫瘍マーカー / 薬剤耐性

Research Abstract

We demonstrated that serum midkine concentrations were a usefulmarker of oral squamous cell carcinoma (OSCC), because midkine protein overexpressed inOSCC tissues and blood of OSCC patients. Furthermore, we showed that the increased S-MKconcentrations in OSCC patients were strongly associated with poor survival. We suggestedthat mechanism by which for midkine inhibited a cell cycle and promoted angiogenesis wasinvolved in anticancer drug resistance. The drug-resistant change by the midkineexpression suppression may be a novel treatment strategy of the cancer therapy.

Research Products

• [Journal Article] Therapeutic approaches targetingmidkine suppress tumor growth and lungmetastasis in osteosarcoma (2012)
  • Author(s): Sueyoshi T, Jono H, Shinriki S, Ota K,Ota T, Tasaki M, Atsuyama E, YakushijiT, Ueda M, Obayashi K, Mizuta H, AndoY
  • Journal Title: CancerLett Volume: 316(1) Pages: 23-30
  • Peer Reviewed
• [Journal Article] Downregulation of midkineinduces cisplatin resistance in humanoral squamous cell carcinoma (2012)
  • Author(s): Ota T, Jono H, Ota K, Shinriki S, UedaM, Sueyoshi T, Nakatani K, Hiraishi Y,Wada T, Fujita S, Obayashi K, ShinoharaM, Ando Y
  • Journal Title: OncolRep Volume: 27(5) Pages: 1674-1680
  • Peer Reviewed
• [Journal Article] Interleukin-6 signallingregulates vascular endothelial growthfactor-C synthesis andlymphangiogenesis in human oralsquamous cell carcinoma (2011)
  • Author(s): Shinriki S, Jono H, Ueda M, Ota K, OtaT, Sueyoshi T, Oike Y, Ibusuki M,Hiraki A, Nakayama H, Shinohara M, AndoY
  • Journal Title: J Pathol Volume: 225(1) Pages: 142-50
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Ota K, Fujimori H, Ueda M, Jono H,Shinriki S, Ota T, Sueyoshi T, Taura M,Taguma A, Kai H, Shinohara M, AndoY
  • Journal Title: Int J Oncol Volume: 37(4) Pages: 797-804
  • Peer Reviewed
• [Journal Article] Midkine expression inmalignant salivary gland tumors andits role in tumor angiogenesis (2010)
  • Author(s): Ota T, Ota K, Jono H, Fujimori H, UedaM,Shinriki S, Sueyoshi T, Shinohara M,Ando Y
  • Journal Title: OralOncol Volume: 46(9) Pages: 657-61
  • Peer Reviewed
• [Presentation] Overexpression of the novel oncogeneSALL4 in oral squamous cell carcinoma (2013)
  • Author(s): Ota K, Ueda M, Shinriki S, Yoshida R,Yasunaga M, Shinohara M, AndoY
  • Organizer: 27th ICMFS World Congress
  • Place of Presentation: Bad Hofgastein, Austria
  • Year and Date: 2013-05-06
• [Presentation] 口腔扁平上皮癌における Zinc finger 蛋白 Sall4 発現についての検討 (2011)
  • Author(s): 太田和俊、 吉田遼司、 植田光晴、 神力 悟、太田智子、末吉貴直、城野博史、安東由喜 男、 篠原正徳
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋国際会議場 名古屋 ポスター
  • Year and Date: 2011-10-28