2012 Fiscal Year Final Research Report
Establishment of dendritic cell-based vaccine in combination with chemotherapy for oral cancer patients
| Project/Area Number |
22592247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University (2011-2012)
Musashino University (2010) |
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Principal Investigator |
OKAMOTO Masato 慶應義塾大学, 医学部, 特任准教授 (10243718)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 口腔癌 / 免疫療法 / 癌ワクチン / 樹状細胞 / 化学療法剤 / 免疫化学療法 |
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| Research Abstract |
We have reported that dendritic cell (DC)-based vaccine is effective in oral cancer patients. Certain chemotherapeutic agents may enhance antitumor effect of cancer vaccine mediated by improvement of immunological condition in cancer patients. In the curr
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[Journal Article] Immuno-Chemoradiotherapy for Patients with Oral Squamous Cell Carcinoma: Augmentation of OK-432-Induced Helper T-Cell 1 Response by 5-FU and X-Ray Irradiation2013
Author(s)
Tano T, Okamoto M, Kan S, Bando T, Goda H, Nakashiro K, Shimodaira S, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Sato M, Yamashita N, Hamakawa H, Kawakami Y
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Journal Title
Neoplasia
Volume: (in press)
Peer Reviewed
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[Journal Article] Fusion cells generated with dendritic cells and whole tumors2013
Author(s)
Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M,Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H.
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Journal Title
OncoImmunol
Volume: (in press)
Peer Reviewed
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[Journal Article] Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes2013
Author(s)
Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Motobe J, Kajihara M, Matsudaira H, Nagatsuma K, Uchiyama K, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H.
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Journal Title
PLOS ONE
Volume: 8 (3)
Pages: e59280
Peer Reviewed
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[Journal Article] Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma2013
Author(s)
Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y, Hamakawa H
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Journal Title
Neoplasia
Volume: 15(3)
Pages: 305-314
Peer Reviewed
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[Journal Article] Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in the patients with advanced pancreatic carcinoma2012
Author(s)
Kimura Y, Tsukada J, Tomoda T, Takahashi H, Imai K, Shimamura K, Sunamura M, Yonemitsu Y, Shimodaira S, Koido S, Homma S, Okamoto M
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Journal Title
Pancreas
Volume: 41(2)
Pages: 195-205
Peer Reviewed
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