2012 Fiscal Year Final Research Report
Sensitization of trigeminal nervous system by infraorbital nerve injury exacerbates the pathophysiology of migraine
| Project/Area Number |
22592257
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUDO Chiho 大阪大学, 歯学部附属病院, 助教 (20533110)
NIWA Hitoshi 大阪大学, 大学院・歯学研究科, 教授 (30218250)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 歯科麻酔学 / 片頭痛 / 三叉神経系 / 慢性口腔顔面痛 / 眼窩下神経結紮 / カプサイシン / pERK |
|---|
| Research Abstract |
We established the chronic constriction injury of the infraorbital nerve (ION-CCI) rat model as a chronic orofacial pain model (neuropathic pain model) by ION loose ligation. At 3 weeks after ION-CCI, the dura was stimulated by 10mM capsaicin, which was the one of the migraine models, followed by checking the expression of the phosphorylated extracellular signal-regulated kinase (pERK) at the trigeminal spinal subnucleus caudalis by immunohistochemical staining method. It showed that the pERK-immunoreactive neurons statistically increased between ovex and 1440 μm caudally in ION-CCI + capisaisin stimulating group compared to capsaicin stimulating group. Taken together, the sensitization of 2nd branch of trigeminal nerve by ION-CCI affected the activation of 1stbranch of trigeminal nerve by capsaicin, suggesting that chronic orofacial pain may exacerbates the pathophysiology of migraine.
|
