2012 Fiscal Year Final Research Report
Development of bioactive orthodontic mini-screw with nano-apatite layer
| Project/Area Number |
22592299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OMATA Kazuhiko 日本歯科大学, 生命歯学部, 非常勤講師 (00434142)
HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 講師 (20228430)
SATOH Tazuko 日本歯科大学, 生命歯学部, 教授 (40095138)
YAMAZAKI Atsusi 早稲田大学, 理工学術院, 教授 (70200649)
ONO Tadao 早稲田大学, 理工学術院, 教授 (90160580)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯科矯正学 |
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| Research Abstract |
In this study, we have developed two surface modifications of titanium alloy that improves its biofunctional activity. The surface of a Ti-6Al-4V disk was modified by applying 3% H2O2 hydrothermal treatment using an autoclave. A nanostructured porous network TiO2 was observed on the treated surface. Furthermore, the TiO2 titan disks were immersed in the supersaturated calcium phosphate solution to formed nano-apatite layer. We evaluated the surface analysis and bioactivities for FGF2 coated modified surfaces. As the results, significantly higher cell proliferation and celldifferentiation were exhibited, and enhanced biofunctional activity.
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