A new pain-related protein kinase signal transduction map: an analysis by phosphor proteomics

2012 Fiscal Year Final Research Report

• Project/Area Number: 22600001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Kagoshima University
• Principal Investigator: KURIHARA Takashi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (60282745)
• Project Period (FY): 2010 – 2012
• Keywords: 痛み / プロテオーム / シグナル伝達 / 脊髄 / リン酸化酵素 / ホールセルパッチクランプ

Research Abstract

We have suggested that CK1δ/ε play important physiological roles in both neuropathic and inflammatory pain signaling, which makes them useful targets for analgesic drug development. We have also identified several potential new CK1 inhibitors. TG003, one of these candidates, was suggested to have potent inhibitory effects on CK1 isoforms in vitro, and showed antinociceptive effects on acute and persistent inflammatory pain models in mice. Our data indicate that TG003 might be a promising lead compound for the development of CK1-targeted new analgesic drugs .

Research Products

• [Journal Article] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain (2009)
  • Author(s): Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S & Tanabe, T
  • Journal Title: Mol. Pain Volume: 5 Pages: 74
  • DOI: DOI:10.1186/1744-8069-5-74
  • Peer Reviewed
• [Presentation] 炎症性疼痛モデルマウスに対する新規カゼインキナーゼ阻害薬の抗侵害効果 (2012)
  • Author(s): 川元大輔、喜井勲、豊本雅靖、朝田俊秀、吉村惠、萩原正敏、宮田篤郎、栗原崇
  • Organizer: 第65回日本薬理学会西南部会
  • Place of Presentation: 熊本
  • Year and Date: 2012-11-23
• [Presentation] On the role of casein kinase 1 in mouse models of inflammatory and neuropathic pain (2012)
  • Author(s): Kurihara, T., Sakurai, E., Asada, T., Yoshimura, M., Miyata, A. & Tanabe, T
  • Organizer: J. Pharmacol. Sci
  • Place of Presentation: 京都
  • Year and Date: 2012-03-15
• [Presentation] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord contributes to neuropathic pain induced by spinal nerve ligation in mice (2011)
  • Author(s): Sakurai, E., Kurihara, T.,, Miyata, A. & Tanabe, T
  • Organizer: J. Pharmacol. Sci
  • Place of Presentation: 雑誌上での誌上開催
  • Year and Date: 20110000
• [Presentation] Activation of casein kinase 1δ/ε in dorsal root ganglia and spinal cord contributes to behavioral hypersensitivity induced by peripheral inflammation in mice (2011)
  • Author(s): Kurihara, T., Sakurai, E., Asada, T., Miyata, A. & Tanabe, T
  • Organizer: J. Pharmacol. Sci
  • Place of Presentation: 雑誌上での誌上開催
  • Year and Date: 20110000
• [Presentation] 脊髄痛覚情報伝達におけるカゼインキナーゼ 1 の役割 (2011)
  • Author(s): 栗原崇、櫻井絵里、朝田俊秀、吉村惠、宮田篤郎、田邊勉
  • Organizer: 第39回薬物活性シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-21
• [Presentation] カゼインキナーゼ 1δ/ε活性化は炎症性疼痛情報伝達に寄与する (2011)
  • Author(s): 栗原崇、櫻井絵里、朝田俊秀、吉村惠、宮田篤郎、田邊勉
  • Organizer: 第64回日本薬理学会西南部会
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-20
• [Presentation] 炎症性疼痛情報伝達におけるカゼインキナーゼ 1δ/ε 活性化の関与 (2011)
  • Author(s): 朝田俊秀、栗原崇、櫻井絵里、吉村惠、宮田篤郎、田邊勉
  • Organizer: 第5回トランスポーター研究会九州部会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-17
• [Remarks] ホームページ
  • URL: http://www.kufm.kagoshima-u.ac.jp/~pharmaco/