2012 Fiscal Year Final Research Report
Development of new therapy for neuropathic cancer pain
| Project/Area Number |
22600009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Hirokazu 東北薬科大学, 薬学部, 准教授 (30360069)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌性疼痛 / 鎮痛 / オピオイドペプチド / μ受容体 / ジーンセラピー |
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| Research Abstract |
Using a mouse model for neuropathic cancer pain, we found that the antinociceptive effects of morphine, oxycodone and methadone were markedly suppressed inthe neuropathic cancer pain. We also found that the antinociceptive effects of morphine, fentanyl and oxycodone are mediated through the activation ofμ-opioid receptor splice variants containing the sequences encoded by exon -1 or exon-4, whereas the antinociceptive effect of amidino-TAPA, which is a new analgesic effective against neuropathic pain, is mediated through the activation of μ -opioid receptor splice variants containing the sequences encoded by exon-1, exon-4, exon-12, exon-13orexon-14.
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Research Products
(59 results)
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[Journal Article] Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Neurosci. Lett
Volume: 495
Pages: 83-87
DOI
Peer Reviewed
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[Journal Article] Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Eur. J. Pharmacol
Volume: 653
Pages: 21-25
DOI
Peer Reviewed
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[Journal Article] Lack of a rewarding effect and a locomotor-enhancing effect of the selective μ-opioid receptor agonist amidino-TAPA2010
Author(s)
H. Mizoguchi, C. Watanabe, S. Osada, M. Yoshioka, Y. Aoki, S. Natsui, A. Yonezawa, S. Kanno, M. Ishikawa, T. Sakurada, S. Sakurada
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Journal Title
Psychopharmacology
Volume: 212
Pages: 215-225
DOI
Peer Reviewed
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