2012 Fiscal Year Final Research Report

MRI quantification of cerebral blood flow and oxygen metabolism at rest and during task performance --- to elucidate the sensing mechanism of fatigue in the brain

Research Project

Project/Area Number	22613003
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Non-invasive neuroimaging
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	TOYODA Hiroshi 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (10558084)
Project Period (FY)	2010 – 2012
Keywords	MRI / 局所脳血流量
Research Abstract	The purpose of this study was to develop a non-invasive method for functional brain imaging both at rest and during tasks, in order to elucidate the sensing mechanisms of fatigue in the human brain. Healthy subjects were measured by a newly developed MRI-based spin labeling methods to quantify cerebral blood flow and oxygen extraction fraction at baseline. The pulse sequences for arterial spin labeling were optimized using multi-slab 3D acquisitions, the measurement accuracy of which was validated. The feasibility of the proposed method was demonstrated by its better time efficiency without sacrificing quantification accuracy.