2012 Fiscal Year Final Research Report
An attempt to deal with saturated fatty acid-induced insulin resistance by the stiffness of the extracellular matrix
| Project/Area Number |
22616005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Mechanobiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
LI Qinkai 徳島大学, 病院, 特任助教 (10571531)
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| Co-Investigator(Kenkyū-buntansha) |
FUNAKI Makoto 徳島大学, 病院, 特任教授 (10467821)
HATA Akiko 徳島大学, 病院, 学術研究員 (20570948)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞外基質 / 硬度 / 脂肪細胞 / 慢性炎症 |
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| Research Abstract |
We previously reported that 3T3-L1 adipocytes exhibit palmitate-induced proinflammatory response most prominently, when they are seeded on 2 -D matrices, which have a stiffness that correspond to that of obese adipose tissues. We then analyzed how mechanical properties of the matrices affect adipocyte functions, when they are seeded in a 3-D environment. Here we report that not only the stiffness of the matrices but also compression of the matrices regulate adipocyte functions.
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