2012 Fiscal Year Final Research Report
Functional analysis of a mechanical stress responsible geneFbxo32 on bone volume regulation
| Project/Area Number |
22616006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Mechanobiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
IZUMI Shinichi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (40264246)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Carolina Andrea 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50437828)
MORIISHI Takeshi 長崎大学, 大学院・医歯薬学総合研究科, 技術職員 (20380983)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMORI Toshihisa 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00252677)
ITO Masako 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10193517)
FUKUYAMA Ryo 広島国際大学, 薬学部, 助教 (20389117)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メカニカルストレス / 遺伝子 / 骨量 / 細胞 / 組織 / 発生・分化 / Fbxo / Runx2 |
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| Research Abstract |
We clarified a part of molecular mechanisms on bone volume regulation by analyzingFbxo32 knockout mice. By bone morphometric analysis after mouse tail suspensionexperiments, it appeared that Fbxo32 gene expression in osteoblasts was associated with the bone volume but not bone density in the bone formation. Further, wild type mice and Fbxo32 knockout mice were administered isoproterenol, similar morphometric value between the femurs was recognized, indicating that Fbxo32 was not involved in a sympathetic nerve-stimulated decrease of bone volume.
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[Journal Article] es bone loss at unloading by promoting osteoclastogenesis2012
Author(s)
Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, and Komori T
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Journal Title
Bone
Volume: 50
Pages: 409-419
Peer Reviewed
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