2011 Fiscal Year Final Research Report

Basic research of a brain functional magnetic resonance imaging based on restrictive water diffusion by using a q-space imaging method

Research Project

Project/Area Number	22650086
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Fusional brain recording science
Research Institution	Fujita Health University
Principal Investigator	YAMADA Masayuki 藤田保健衛生大学, 医療科学部, 准教授 (40383773)
Project Period (FY)	2010 – 2011
Keywords	脳機能計測
Research Abstract	The purpose of this study was to seek application of a novel q-space magnetic resonance imaging(QSI) method for detecting neural activity in rat brain. In this study, we attempted to utilize the QSI method to an imaging analysis of middle cerebral artery occlusion(MCAO) rat model as an initial work and to visualize ischemic area by using "Kurtosis" mapping. Furthermore, activity induced manganese enhanced magnetic resonance imaging(AIM-MRI) was also optimized as a tool to confirm the neural activity in rat brain in vivo. Results of this initial study suggest that the QSI is a useful tool for noninvasive neuroimaging analysis in rat brain, albeit further study is needed.

(4 results)