2011 Fiscal Year Final Research Report
Visualization of chromosome aneuploidy in living embryo
| Project/Area Number |
22650096
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University (2011)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
YAMAGATA Kazuo 大阪大学, 微生物病研究所, 特任准教授 (10361312)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 初期胚発生 / ライブセルイメージング / 染色体異数性 / トリソミー |
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| Research Abstract |
Chromosomal aneuploidy in oocyte and early embryo is major cause of early pregnancy loss and evokes severe chromosome disorder such as Down syndrome after birth. However, the mechanisms for the chromosome abnormality were still enigmatic due to the experimental limitations inherent to the early embryo. In this study, we established a new protocol to visualize the chromosomal aneuploidy in living embryo by developing the fluorescently probe that binds to the specific chromosomes.
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[Journal Article] Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling2011
Author(s)
Hayashi-Takanaka Y, Yamagata K, Wakayama T, Stasevich TJ, Kainuma T, Tsurimoto T, Tachibana M, Shinkai Y, Kurumizaka H, Nozaki N, Kimura H.
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Journal Title
Nucleic Acid Research
Volume: 39(15)
Pages: 6475-88
DOI
Peer Reviewed
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