2012 Fiscal Year Final Research Report
Biological effects of therapeutic exercise on osteoarthritis of kneeand developmental study of biomarker
| Project/Area Number |
22650130
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
OKITA Minoru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50244091)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Jyunya 長崎大学, 大学病院, 理学療法士 (20584080)
NAKANO Jiro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20380834)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 変形性膝関節症 / 痛み / 運動療法 / 持続的他動運動 / 筋力トレーニング / 抗炎症性サイトカイン |
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| Research Abstract |
The objective of this study is to present the basic data for biological effects of therapeutic exercise on osteoarthritis of knee. We simulated two kinds of therapeutic exercises like continuous passive motion and low-intensity exercise by neuromuscular electrical stimulation, and examined the effects of therapeutic exercisesduring the early stages of arthritis on inflammation and pain-related behavior in rat’sarthritis model. As a result, therapeutic exercises significantly accelerated the amelioration of joint swelling and pressure withdrawal threshold and increased the mechanical withdrawal threshold immediately after treatment. We hypothesized that the mechanism of such a biological effect by therapeutic exercise related to the up-regulation of anti-inflammatory cytokine on surrounding tissue of joint. Additionally, we assumed that anti-inflammatory cytokine was able to use as the biomarker.
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[Presentation] Continuous passive motion during the early stages of arthritis reduces joint swelling and improves pain-related behavior in rats2012
Author(s)
Kondo Y, Yoshino T, Morimoto Y, Sasabe R, Hamaue Y, Sekino Y, Sakamoto J, Nakano J, Yoshida Y, Okita M
Organizer
14th World Congresson Pain
Place of Presentation
Milan, Italy
Year and Date
20120827-31
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[Presentation] 大腿骨近位部骨折術後の痛みの発生状況に関する調査2011
Author(s)
片岡英樹, 西川正吾, 渋谷美帆子, 岩佐恭平, 山口紗智, 村上正寛, 中川勇樹, 吉田奈央, 鵜殿紀子, 濱崎 忍, 三村国秀, 山下潤一郎, 坂本淳哉, 中野治郎, 沖田実
Organizer
第46回日本理学療法学術大会
Place of Presentation
宮崎
Year and Date
20110527-29
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[Presentation] 大腿骨近位部骨折術後の痛みの発生状況に関する実態調査2010
Author(s)
坂本淳哉, 片岡英樹, 吉田奈央, 山口紗智, 西川正吾, 村上正寛, 中川勇樹, 鵜殿紀子, 渋谷美帆子, 岩佐恭平, 濱崎 忍, 三村国秀, 山下潤一郎, 中野治郎, 沖田 実
Organizer
第45回日本理学療法学術大会
Place of Presentation
岐阜
Year and Date
20100527-29
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[Presentation] 慢性痛の末梢機構2010
Author(s)
沖田 実, 中野治郎, 坂本淳哉, 森本陽介, 濱上洋平
Organizer
第15回理学療法の医学的基礎研究会学術集会
Place of Presentation
名古屋
Year and Date
2010-05-26
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[Remarks] 週刊誌取材報道週刊文春4月4日号(2013), pp48-51.
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[Remarks] 学会賞受賞第47回日本理学療法学術大会奨励賞演題名:ラット膝関節炎モデルに対する持続的他動運動の早期介入が腫脹や痛みにおよぼす影響演者:吉野孝明, 近藤康隆, 佐々部陵, 濱上陽平, 関野有紀, 坂本淳哉, 中野治郎, 沖田実:.
