2011 Fiscal Year Final Research Report
Inhibitory effects of exercise on progression of obesity-related liver diseases and development of glyco-biomarkers to scale the pathophysiology of the liver diseases
| Project/Area Number |
22650162
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
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| Co-Investigator(Kenkyū-buntansha) |
AJISAKA Ryuichi 筑波大学, 体育系, 教授 (70151058)
FUKUDA Kuniaki 筑波大学, 医学医療, 講師 (50447257)
OKAMOTO Yoshikazu 筑波大学, 医学医療, 講師 (90420083)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肥満 / 脂肪性肝疾患 / 運動療法 / 糖鎖医学 / バイオマーカー |
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| Research Abstract |
In management of obesity-related liver diseases, that is, non-alcoholic fatty liver diseases, it is important to increase a utilization of glucose in the skeletal muscles and thereby to improve the insulin-resistance. Therefore, in subjects with non-alcoholic fatty liver diseases, it is also important to maintain the volume of skeletal muscles by appropriate exercise. In the assessment of effects of exercise on liver pathophysiology of non-alcoholic fatty liver diseases, we need to explore novel biomarkers that can reflect the status of liver pathophysiology in terms of steatosis, inflammation, and fibrosis, and to develop a non-invasive measurement system of these biomarkers. In this research project, using the serum samples of middle-aged obese men who joined a weight-losing course, we explored novel biomarkers that can scale the improvement of liver pathophysiology induced by exercise. We measured an enzyme activity of N-acetylglucosaminyltransferase V (GnT-V) in the serum samples as a glyco-biomaker. Exercise increased the energy consumption, maintained the lean body mass, and decreased the serum levels of ferritin and TBARS, an oxidative stress marker, in comparison with diet restriction. Taken together, it is likely that serum levels of ferritin and TBARS are useful biomarkers to scale the effects of exercise on liver pathophysiology in obese men. Exploration of novel glycol-biomarkers is being performed.
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