2012 Fiscal Year Final Research Report
Analyses of the mechanism of hypertension by means of optical imaging
| Project/Area Number |
22650165
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Kanto Gakuin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Katsushige 駒沢女子大学, 人間健康学部, 教授 (80291342)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 高血圧 / 循環中枢 / 光学計測 / 膜電位感受性色素 / 機能構築 / ラット胚 |
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| Research Abstract |
We studied the mechanism of hypertension in view of functional abnormality of the cardiovasucular center. Brainstem preparations with the vagus and glossopharyngeal nerves attached were dissected from E14-E16 control and spontaneous hypertensive rat (SHR) embryos. Neural responses to vagus or glossopharyngeal nerve stimulation were detected by means of multiple-site optical imaging. From the analysis of signal waveforms, we identified motor and sensory nuclei related to the vagus and glossopharyngeal nerves. In the nucleus of the tractus solitarius, developmental processes of the excitatory postsynaptic potential (EPSP) were similar between the control and SHR embryos.
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