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2011 Fiscal Year Final Research Report

Development of the new method to control the molecular motor enzyme

Research Project

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Project/Area Number 22651048
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionTokyo Institute of Technology

Principal Investigator

HISABORI Toru  東京工業大学, 資源化学研究所, 教授 (40181094)

Co-Investigator(Renkei-kenkyūsha) MASUDA Shinji  東京工業大学, 大学院・生命理工学研究科, 准教授 (30373369)
IKEUCHI Masahiko  東京大学, 大学院・総合文化研究科, 教授 (20159601)
TAKEUCHI Shoji  東京大学, 生産技術研究所, 准教授 (90343110)
Project Period (FY) 2010 – 2011
Keywords分子マニピュレーション / 光スイッチ
Research Abstract

Based on our hypothesis that the activity of ATP synthase can be regulated by the relative slippage of two alpha-helices of the gamma subunit, we intended to restrict the movement of two alpha-helices and studied the change in the enzyme activity. Then we tried to introduce a novel artificial switch into the gamma subunit to control the enzyme activity using a certain domain of light-responsible protein. In addition, the highly sensitive monitoring system to measure the enzyme activity at single molecule level at the aqueous phase was developed.

  • Research Products

    (2 results)

All 2012 Other

All Presentation (1 results) Remarks (1 results)

  • [Presentation] 葉緑体ATP合成酵素の活性制御には、γサブユニットのα-ヘリックスのズレが関与する2012

    • Author(s)
      砂村栄一郎、紺野宏記、久堀徹
    • Organizer
      第53回日本植物生理学会年会
    • Place of Presentation
      京都産業大学
    • Year and Date
      2012-03-18
  • [Remarks]

    • URL

      http://www.res.titech.ac.jp/~junkan/index-j.html

URL: 

Published: 2013-07-31  

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